Dr. Anthony E. Kline (Professor of Physical Medical & Rehabilitation (PMR), Psychology, Critical Care Medicine, Center for Neuroscience, and Safar Center Associate Director), was awarded an R01 grant to study the efficacy of human neural stem cells on motor, cognitive, and affective outcomes after controlled cortical impact injury in adult rats of both sexes. The project is in collaboration with Co-MPI Margarita Gutova, MD who is an Associate Research Professor in the Department of Developmental and Stem Cell Biology at City of Hope, Duarte, CA. PMR Assistant Professor and Safar Center Associate Director Corina Bondi, PhD, and Eric Lagasse, PharmD, PhD, Associate Professor in the Department of Pathology at the University of Pittsburgh are serving as Co-I’s. The aims of the grant are to determine various doses and timing of intranasal administration of human neural stem cells, potential additive efficacy when combined with environmental enrichment – a preclinical model of neurorehabilitation – and elucidate potential mechanisms.