An integral component of the collaborative research and educational environment of the Safar Center is the Neurointensive Critical Care and Resuscitation Research Journal Club
The Safar Center for Resuscitation Research brings together many different departments and disciplines within the University of Pittsburgh School Of Medicine, the Children’s Hospital of Pittsburgh, and beyond. An integral component of the collaborative research and educational environment of the Safar Center is the Neurointensive Critical Care and Resuscitation Research Journal Club. The Journal Club is a casual space where students, trainees, and faculty of all levels meet to discuss the latest articles in the field of neurocritical care, neuroscience, neurotrauma, and resuscitation. The Journal Club meets every Friday.
|Madha, Jackson||12/19/2014||A clinical trial of progesterone for severe traumatic brain injury.
Preimplantation factor promotes neuroprotection by targeting microRNA let-7.
|Hagos, Pang||12/5/2014||Population pharmacokinetics of unbound hydrocortisone in critically ill Neonates and infants with vasopressor-resistant hypotension.
Pro-inflammatory T-lymphocytes rapidly infiltrate into the brain and contribute to neuronal injury following cardiac arrest and cardiopulmonary resuscitation.
|Browning||11/21/2014||What is wrong with the tenets underpinning current management of severe traumatic brain injury?
A conceptual approach to managing severe traumatic brain injury in a time of uncertainty.
|Madha||11/14/2014||The Effect of Posttraumatic Hypothermia on Diffuse Axonal Injury Following Parasagittal Fluid Percussion Brain Injury in Rats.|
|Carlson||11/7/2014||Sleep Restriction Impairs Blood–Brain Barrier Function.|
|Hagos||10/31/2014||Traumatic brain injury causes selective, CD74-dependant peripheral lymphocyte activation that exacerbates neurodegeneration.|
|Madha||10/24/2014||In vivo leukocyte-mediated brain microcirculatory inflammation: a comparison of osmotherapies and progesterone in severe traumatic brain injury.|
|Pang||10/16/2014||Randomized controlled trial comparing cerebral perfusion pressure–targeted therapy versus intracranial pressure–targeted therapy for raised intracranial pressure due to acute CNS infections in children.|
|Hagos||9/26/2015||Differential roles of microglia and monocytes in the inflamed central nervous system.|
|Oana Bondi, Leary||9/5/2014||Administration of low dose methamphetamine 12 h after a severe traumatic brain injury prevents neurological dysfunction and cognitive impairment of rats.
MMP-9 inhibitor SB-3CT attenuates behavioral impairments and hippocampal loss after traumatic brain injury.
|Osier, Pang||8/22/2014||The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: A novel mouse model of chronic traumatic encephalopathy.
Matrix metalloproteinase-2 and metalloproteinase-9 activities are associated with blood-brain barrier dysfunction in an animal model of severe sepsis.
|Liput||8/15/2014||Effects of adenosine monophosphate on induction of therapeutichypothermia and neuronal damage after cardiopulmonaryresuscitation in rats.|
|Carlson, Hagos||8/8/2014||Intravenous Transplants of Human Adipose-Derived Stem Cell Protect the Brain for Traumatic Brain Injury-Induced Neurodegeneration and Motor and Cognitive Impairments: Cell Graft Biodistribution and Soluble Factors in Young and Aged Rats.
Nrf2 Upregulates ATP Binding Cassette Transporter Expression and Activity at the Blood-Brain and Blood-Spinal Cord Barriers.
|Dezfulian, Cheng||7/25/2014||Capillary pericytes regulate cerebral blood flow health and disease.
Rodent model of direct blast injury.
|Brockman, Lamade||7/18/2015||Blood component transfusion increases the risk of death in children with traumatic brain injury.
A mitochondrial pathway for biosynthesis of lipid meditaors.
|Hagos, Oana Bondi||7/11/2014||Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway.
A semicircular controlled cortical impact produces long-term motor and cognitive dysfunction that correlates well with damage to both the sensorimotor cortex and hippocampus.
|Barton, Simon||6/27/2014||Stress-dose hydrocortisone reduces critical illness-related corticosteroid insufficiency associated with severe traumatic brain injury in rats.
Recombinant human interleukin-1 receptor antagonist in severe traumatic brain injury: a phase II randomized control trial.
|Failla||6/20/2014||White matter/gray matter contrast changes in chronic and diffuse traumatic brain injury.|
|Kochanek||6/13/2014||Heterogeneity affecting outcome from acute stroke therapy: Making reperfusion worse.
Cerebral ischemia and reperfusion: The pathophysiologie concept as a basis for clinical therapy.
|Adam||6/6/2014||Gibenclamide reduces secondary brain damage after experimental traumatic brain injury.|
|Newmeyer||5/30/2014||Randomized Controlled Trial Comparing Cerebral Perfusion Pressure-Targeted Therapy Versus Intracranial Pressure-Targeted Therapy for Raised Intracranial Pressure due to Acute CNS Infections in Children.|
|Juengst, Kumar||5/23/2014||Comparison of several prognostic tools in traumatic brain injury including S100B.
Long-term survival after traumatic brain injury: A population-based analysis controlled for nonhead trauma.
|Diamond||5/16/2014||Inflammasome proteins in cerebrospinal fluid of brain injured patients as biomarkers of functional outcome.|
|Ferguson||5/9/2014||Intracranial Pressure Monitoring in Children With Severe Traumatic Brain Injury.|
|Simon, Kim-Campbell||5/2/2015||Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-Red fluorescent protein knock-in mice.
Extra cellular lactate increase is predominantly nonischemic in patients with severe traumatic brain injury.
|Leary, Ritter||4/25/2014||Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury.
Epidemiology, severity classification and outcome of moderate and severe traumatic brain injury: a prospective multicenter study.
|Faila, Harun||4/18/2014||Robust training attenuates TBI-induced deficits in reference and working memory on the radial 8-arm maze.
Dopamine protects neurons against glutamate-induced excitotoxicity.
|Uray, Carlson||4/10/2014||Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest.
Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy.
|Ferguson, Dezfulian||4/4/2014||Increased intracranial pressure after diffuse traumatic brain injury exacerbates neuronal somatic membrane poration but not axonal injury: evidence for primary intracranial pressure-induced neuronal perturbation.
Circulation nitrite contributes to cardioprotection by remote ischemic preconditioning.
|Ritter, Kumar||3/28/2014||Neuroimaging, behavioral, and psychological sequelea of repetitive combined blast/impact mild traumatic brain injury in Iraq and Afghanistan War veterans.
Inflammation and white matter degeneration persist for years after a single traumatic brain injury.
|Pang, Failla||3/21/2014||Lipopolysaccharide-induced microglial activation neuroprotection against experimental brain injury is independent of hemotogenous TLR4.
Reversal of established traumatic brain injury-induced, anxiety-like behavior in rats after delayed, post-injury neuroimmune suppression.
|Harun, Simon||3/14/2014||Activation of D1 dopamine receptors induces emergence from isoflurane general anesthesia.
Pyroptotic neuronal cell death mediated by the AIM2 inflammasome.
|Coppler||3/7/2014||Adenosine, lidocaine, and MG2+ (ALMTM) increases survival and corrects coagulopathy after eight-minute asphyxia cardiac arrest in the rat.
Propofol impairs neurogenesis and neurologic recovery and increases mortality rate in adult rats after traumatic brain injury.
|2/28/2014||Disrupted modular organization of resting-state cortical functional connectivity in U.S. military personnel following concussive ‘mild’ blast-related traumatic brain injury.
Environmental enrichment may protect against hippocampal atrophy in the chronic stages of traumatic brain injury.
|2/7/2014||Rehabilitation improves behavioral recovery and lessens cell death without affecting iron, ferritin, transferrin, or inflammation after intracerebral hemorrhage in rats.
Neuroprotective, neuroplastic, and neurobehavorial effects of daily treatment with levetiracetam in experimental traumatic brain injury.
|Garman, Simon||1/31/2014||Diffusion tensor imaging reveals white matter injury in a rat model of repetitive blast-induced traumatic brain injury
Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation
|Brockman||1/24/2014||Glibenclamide is superior to decompressive craniectomy in a rat model of malignant stroke.|
|Failla||1/17/2014||Alteration in BNDF and Its Receptors, Full-lenght and Truncated TrKB and P75NRT Following Penetrating Traumatic Brain Injury|