Collaborative research led by former Safar Center investigator Dr. Ruchira Jha, currently Director of Neurocritical Care at the Barrow Neurological Institute in Phoenix, AZ was published in the journal Neuron. The work described a unique atlas of >330,000 cells in the brain and how they response to TBI in three murine models. Called CEREBRI (Cellular Exploration and REsolution of BRain Injury), the atlas addresses the temporal changes in cell profiles and gene expression patterns across TBI severity (including models of cerebral contusion and concussion). It also features TBI complicated by the common second insult of hemorrhagic shock seen in critically ill patients. It provides rich and novel insight into the inflammatory response to TBI and addressed issues such as sex and time post-injury, among others. It features the collaborative expertise of Drs. Gary Kohanbash (Dept. of Neurological Surgery at UPMC Children’s Hospital of Pittsburgh [CHP]), in single cell methods, Dhivyaa Rajasundaram (Dept. of Pediatrics, UPMC CHP), in informatics, Dennis Simon (Dept. of Critical Care Medicine, UPMC CHP) in neuroinflammation, and Patrick Kochanek, MD (Safar Center director) in TBI models and therapy development. Funded by NINDS and the Chuck Noll Foundation, it has garnered considerable attention including a social media post on Linked In from Dr. Monica Bertagnolli, Director of the National Institutes of Health. We hope that the atlas will be used by the field and advance new therapies for TBI across the spectrum in insult severity.