The past year was extremely productive for Safar Center investigators. In 2018, over 70 articles were published by our faculty and trainees from the departments of Critical Care Medicine, Neurological Surgery, Physical Medicine and Rehabilitation, Pediatrics, Emergency Medicine, and Anesthesiology, amongst others. The list below consists of 25 articles selected by the Safar Center Director from the past year we’d like to highlight:

 24 vs. 72 Hours of Hypothermia for Pediatric Cardiac Arrest: A Pilot, Randomized Controlled Trial. Fink EL, Clark RSB, Berger RP, Fabio A, Angus DC, Watson RS, Gianakas JJ, Panigrahy A, Callaway CW, Bell MJ, Kochaneka PM. Resuscitation. 2018 Feb 14.

Brain-Specific Serum Biomarkers Predict Neurological Morbidity in Diagnostically Diverse Pediatric Intensive Care Unit Patients. Au AK, Bell MJ, Fink EL, Aneja RK, Kochanek PM, Clark RSB. Neurocrit Care. 2018 Feb;28(1):26-34.

Empowerment of 15-lipoxygenase catalytic competence in selective oxidation of membrane ETE-PE to ferroptotic death signals, HpETE-PE. Anthonymuthu TS, Kenny EM, Shrivastava IH, Tyurina YY, Hier ZE, Ting HC, Dar H, Tyurin VA, Nesterova A, Amoscato AA, Mikulska-Ruminska K, Rosenbaum JC, Mao G, Jinming Z, Conrad M, Kellum JA, Wenzel SE, VanDemark AP, Bahar I, Kagan VE, Bayir H. J Am Chem Soc. 2018 Dec 7. [Epub ahead of print]

Environmental enrichment, alone or in combination with various pharmacotherapies, confers marked benefits after traumatic brain injury. de la Tremblaye PB, Cheng JP, Bondi CO, Kline AE.Neuropharmacology. 2018 Feb 27. [Epub ahead of print] Review.

Epidemiology of Comorbid Conditions Among Adults 50 Years and Older With Traumatic Brain Injury. Kumar RG, Juengst SB, Wang Z, Dams-OʼConnor K, Dikmen SS, OʼNeil-Pirozzi TM, Dahdah MN, Hammond FM, Felix ER, Arenth PM, Wagner AK. J Head Trauma Rehabil. 2018 Jan/Feb;33(1):15-24.

 Exploratory Application of Neuropharmacometabolomics in Severe Childhood Traumatic Brain Injury. Hagos FT, Empey PE, Wang P, Ma X, Poloyac SM, Bayir H, Kochanek PM, Bell MJ, Clark RSB. Crit Care Med. 2018 Sep;46(9):1471-1479.

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury. Kenny EM, Fidan E, Yang Q, Anthonymuthu TS, New LA, Meyer EA, Wang H, Kochanek PM, Dixon CE, Kagan VE, Bayır H. Crit Care Med. 2018 Dec 6. [Epub ahead of print]

Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain. Jackson TC, Kotermanski SE, Kochanek PM. Dev Neurosci. 2018 Nov 6:1-12.

Intracranial Pressure Trajectories: A Novel Approach to Informing Severe Traumatic Brain Injury Phenotypes. Jha RM, Elmer J, Zusman BE, Desai S, Puccio AM, Okonkwo DO, Park SY, Shutter LA, Wallisch JS, Conley YP, Kochanek PM.Crit Care Med. 2018 Aug 16.

Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond. Kochanek PM, Dixon CE, Mondello S, Wang KKK, Lafrenaye A, Bramlett HM, Dietrich WD, Hayes RL, Shear DA, Gilsdorf JS, Catania M, Poloyac SM, Empey PE, Jackson TC, Povlishock JT. Front Neurol. 2018 Aug 7;9:640.

Novel therapies for combating chronic neuropathological sequelae of TBI. Ikonomovic MD, Abrahamson EE, Carlson SW, Graham SH, Dixon CE. Neuropharmacology. 2018 Jun 20. pii: S0028-3908(18)30310-1. [Epub ahead of print] Review.

Oxidative Stress Induces Release of 2′-AMP from Microglia. Jackson TC, Kotermanski Brain Res. 2018 Nov 2. pii: S0006-8993(18)30554-7. [Epub ahead of print]

Oxidized phospholipid signaling in traumatic brain injury. Anthonymuthu TS, Kenny EM, Lamade AM, Kagan VE, Bayır H. Free Radic Biol Med. 2018 Jun 30;124:493-503. [Epub ahead of print] Review

Paths to successful translation of new therapies for severe TBI in the golden age of traumatic brain injury research: A Pittsburgh vision. Kochanek PM, Jackson TC, Jha R, Clark RSB, Okonkwo DO, Bayir H, Poloyac SM, Wagner AK M.D, Empey PE, Conley YP, Bell MJ, Kline AE, Bondi CO, Simon DW, Carlson SW, Puccio AM, Horvat CM, Au A, Elmer J, Treble-Barna A, Ikonomovic M, Shutter L, Taylor DL, Stern AM, Graham SH, Kagan VE, Jackson EK, Wisniewski SR, Dixon CE. J Neurotrauma. 2018 Dec 6.

Phenotyping Cardiac Arrest: Bench and Bedside Characterization of Brain and Heart Injury Based on Etiology. Uray T, Lamade A, Elmer J, Drabek T, Stezoski JP, Missé A, Janesko-Feldman K, Garman RH, Chen N, Kochanek PM, Dezfulian C; University of Pittsburgh Post-Cardiac Arrest Service. Crit Care Med. 2018 Mar 10.[Epub ahead of print]

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium. Dar HH, Tyurina YY, Mikulska-Ruminska K, Shrivastava I, Ting HC, Tyurin VA, Krieger J, St Croix CM, Watkins S, Bayir E, Mao G, Ambruster C, Kapralov A, Wang H, Parsek MH, Anthonymuthu TS, Ogunsola AF, Flitter BA, Freedman CJ, Gaston JR, Holman TR, Pilewski JM, Greenberger JS, Mallampalli RK, Doi Y, Lee JS, Bahar I, Bomberger JM, Bayır H, Kagan VE. J Clin Invest. 2018 Sep 10. [Epub ahead of print]

Regionally clustered ABCC8 polymorphisms in a prospective cohort predict cerebral oedema and outcome in severe traumatic brain injury. Jha RM, Koleck TA, Puccio AM, Okonkwo DO, Park SY, Zusman BE, Clark RSB, Shutter LA, Wallisch JS, Empey PE, Kochanek PM, Conley YP. J Neurol Neurosurg Psychiatry. 2018 Apr 19. pii: jnnp-2017-317741. [Epub ahead of print]

Serum-based phospho-neurofilament-heavy protein as theranostic biomarker in three models of traumatic brain injury: an Operation Brain Trauma Therapy (OBTT) study. Yang Z, Zhu T, Mondello S, Akel M, Wong AT, Kothari IM, Lin F, Shear DA, Gilsdorf J, Leung LY, Bramlett HM, Dixon CE, Dietrich WD, Hayes RL, Povlishock J, Tortella FC, Kochanek PM, Wang KKW. J Neurotrauma. 2018 Jul 10. [Epub ahead of print]

Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor. Krainz T, Lamade AM, Du L, Maskrey TS, Calderon MJ, Watkins SC, Epperly MW, Greenberger JS, Bayır H, Wipf P, Clark RSB. ACS Chem Biol. 2018 Sep 14. [Epub ahead of print]

Systemic administration of donepezil attenuates the efficacy of environmental enrichment on neurobehavioral outcome after experimental traumatic brain injury. Bondi CO, Yelleswarapu NK, Day-Cooney J, Memarzadeh K, Folweiler KA, Bou-Abboud CE, Leary JB, Cheng JP, Tehranian-DePasquale R, Kline AE. Restor Neurol Neurosci. 2018;36(1):45-57.

Systemic estrone production and injury induced sex hormone steroidogenesis after severe traumatic brain injury: a prognostic indicator of TBI-related mortality. Rakholia MV, Kumar RG, Oh BM, Ranganathan PR, Berga S, Kochanek PM, Wagner AK M.D. J Neurotrauma. 2018 Jun 27. [Epub ahead of print]

The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest. Wallisch JS, Janesko-Feldman K, Alexander H, Jha RM, Farr GW, McGuirk PR, Kline AE, Jackson TC, Pelletier MF, Clark RSB, Kochanek PM, Manole MD. Pediatr Res. 2018 Oct 26.[Epub]

Traumatic Brain Injury and Infectious Encephalopathy in Children From Four Resource-Limited Settings in Africa. Fink EL, von Saint Andre-von Arnim A, Kumar R, Wilson PT, Bacha T, Aklilu AT, Teklemariam TL, Hooli S, Tuyisenge L, Otupiri E, Fabio A, Gianakas J, Kochanek PM, Angus DC, Tasker RC; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, PALISI Global Health Subgroup, and Prevalence of Acute Critical Neurological Disease in Children: A Global Epidemiological Assessment (PANGEA) Investigators.Pediatr Crit Care Med. 2018 Apr 16.  [Epub ahead of print]