The 19th Annual Safar Symposium, held as a hybrid event on May 26-27, 2021, introduced attendees to Freedom House 2.0, in addition to the symposium’s traditional program of investigator presentations, a keynote address, multi-departmental trainees’ research day, and the WISER simulation lecture session. Freedom House 2.0 (FH2.0) is a 21st century iteration of the paramedic training established by Peter Safar in the late 1960s that led to the creation of the Freedom House ambulance service in Pittsburgh’s Hill District.