Recent Publications

February/March/April 2008

Au AK, Ray PE, McBryde KD, Newman KD, Weinstein SL, Bell MJ:  Incidence of postoperative hyponatremia and complications in critically-ill children treated with hypotonic and normotonic solutions.  J Pediatr 152:33-38, 2008.

Bell MJ, Carpenter J, Au AK, Keating RF, Myseros JS, Yaun A, Weinstein S:  Development of a Pediatric Neurocritical Care Service.  Neurocritical Care (in press).

Bayır H, Kagan VE:  Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis - there is nothing more practical than a good theory. Crit Care 2008 Feb 18;12:206 [Epub ahead of print].

Clark RS, Bayır H, Chu CT, Alber SM, Kochanek PM, Watkins SC:  Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness. Autophagy 4:88-90, 2008.

Dennis AM, Haselkorn L, Vagni VA, Garman R, Janesko-Feldman K, Bayır H, Clark RSB, Jenkins LW, Dixon CE,  Kochanek PM:  Hemorrhagic Shock after Experimental Traumatic Brain Injury in Mice: Effect on Neuronal Death. J Neurotrauma (in press).

Drabek T, Han F, Garman RH, Stezoski J, Tisherman SA, Stezoski SW, Morhard RC, Kochanek PM:  Assessment of the delta opioid agonist DADLE in a rat model of lethal hemorrhage treated by emergency preservation and resuscitation.  Resuscitation 77:220-228, 2008.

Foley LM, Hitchens TK, Melick JA, Bayır H, Ho C, Kochanek PM:  Effect of inducible nitric oxide synthase on cerebral blood flow after experimental traumatic brain injury in mice.  J Neurotrauma 25:299-310, 2008.

Hartman ME, Watson RS, Linde-Zwirble WT, Clermont G, Weissfeld L, Lave JR, Kochanek PM, Angus DC:  Pediatric traumatic brain injury is inconsistently regionalized in the US.  Pediatrics (in press).

Hoffman AN, Malena RR, Westergom BP, Luthra P, Cheng JP, Aslam HA, Zafonte RD, Kline AE: Environmental enrichment-mediated functional improvement after experimental traumatic brain injury is contingent on task-specific neurobehavioral experience.  Neurosci Lett 431:226-230, 2008. 

Kochanek PM, Berger RP, Bayr H, Wagner AK, Jenkins LW, Clark RS:  Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making.  Curr Opin Crit Care 14:135-141, 2008.

Lai Y, Chen Y, Watkins SC, Nathaniel PD, Guo F, Kochanek PM, Jenkins LW, Szabo C, Clark RS:  Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury.  J Neurochem 104:1700-1711, 2008.

Sharangpani A, Takanohashi A, Bell MJ:  Caspase activation in fetal rat brain following experimental intrauterine inflammation. Brain Res 1200C:138-145, 2008.

Wu X, Drabek T, Tisherman SA, Henchir J, Stezoski SW, Culver S, Stezoski J, Jackson EK, Garman R, Kochanek PM:  Emergency preservation and resuscitation with profound hypothermia, oxygen, and glucose allows reliable neurological recovery after 3 h of cardiac arrest from rapid exsanguination in dogs. J Cereb Blood Flow Metab 28:302-311, 2008.

January 2008

Berger RP, Beers SR, Richichi R, Wiesman D, Adelson PD:  Serum biomarker concentrations and outcome after pediatric traumatic brain injury.  J Neurotrauma 24:1793-1801, 2007.

Buttram SD, Wisniewski SR, Jackson EK, Adelson PD, Feldman K, Bayir H, Berger RP, Clark RS, Kochanek PMMultiplex assessment of cytokine and chemokine levels in cerebrospinal fluid following severe pediatric traumatic brain injury: Effects of moderate hypothermia. J Neurotrauma 24:1707-1718, 2007.

Janata A, Bayegan K, Weihs W, Schratter A, Holzer M, Frossard M, Sipos W, Springler G, Schmidt P, Sterz F, Losert UM, Laggner AN, Kochanek PM, Behringer W:  Emergency preservation and resuscitation improve survival after 15 minutes of normovolemic cardiac arrest in pigs.  Crit Care Med 35:2785-2791, 2007.

Kagan VE, Jiang J, Bayır H, Stoyanovsky DA:  Targeting nitroxides to mitochondria: location, location, location, and …concentration: highlight commentary on "Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide".  Free Radic Biol Med 43:348-350, 2007.

Kapralov AA, Kurnikov IV, Vlasova II, Belikova NA, Tyurin VA, Basova LV, Zhao Q, Tyurina YY, Jiang J, Bayır H, Vladimirov YA, Kagan VE:  The Hierarchy of structural transitions induced in cytochrome c by anionic phospholipids determines its peroxidase activation and selective peroxidation during apoptosis in cells.  Biochemistry 46:14232-14244, 2007.

Lai Y, Hickey RW, Chen Y, Bayır H, Sullivan ML, Chu CT, Kochanek PM, Dixon CE, Jenkins LW, Graham SH, Watkins SC, Clark RS:  Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester.  J Cereb Blood Flow Metab 28:540-550, 2008.

Lo BM, Quinn SM, Hostler D, Callaway CW:  Rescue shock outcomes during out-of-hospital cardiac arrest.  Resuscitation 75:469-475, 2007.

Moore TM, Callaway CW, Hostler D:  Core temperature cooling in healthy volunteers after rapid intravenous infusion of cold and room temperature saline solution.  Ann Emerg Med 51:153-159, 2008.

Rittenberger JC, Hostler DP, Tobin T, Gaines J, Callaway CW:  Predictors of ROSC in witnessed aeromedical cardiac arrests.  Resuscitation 76:43-64, 2008

Tortorici MA, Kochanek PM, Poloyac SM:  Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system.  Crit Care Med 35:2196-2204, 2007. Review.

Venneti S, Wagner AK, Wang G, Slagel SL, Chen X, Lopresti BJ, Mathis CA, Wiley CA:  The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging.  Exp Neurol 207:118-127, 2007.

August/September/October 2007

Bayır H, Tyurin VA, Tyurina YY, Viner R, Ritov V, Amoscato AA, Zhao Q, Zhang XJ, Janesko-Feldman KL, Alexander H, Basova LV, Clark RS, Kochanek PM, Kagan VE: Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis.  Ann Neurol 62:154-169, 2007.

Cao G, Xing J, Xiao X, Liou AK, Gao Y, Yin XM, Clark RS, Graham SH, Chen J:  Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury.  Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury.  J Neurosci 27:9278-9293, 2007.

Clark RS, Vagni VA, Nathaniel PD, Jenkins LW, Dixon CE, Szabo C:  Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice.  J Neurotrauma 24:1399-1405, 2007.

Drabek T, Fisk JA, Dixon CE, Garman RH, Stezoski J, Wisniewski SR, Wu X, Tisherman SA, Kochanek PM:  Prolonged deep hypothermic circulatory arrest in rats can be achieved without cognitive deficit.  Life Sci 81:543-552, 2007.

Drabek T, Stezoski J, Garman RH, Han F, Henchir J, Tisherman SA, Stezoski SW, Kochanek PM:  Exsanguination cardiac arrest in rats treated by 60 min, but not 75 min, emergency preservation and delayed resuscitation is associated with intact outcome. Resuscitation 75:114-123, 2007.

Fink EL, Callaway CW, Tisherman SA, Kochanek PM:  Hypothermia in traumatic brain injury.  Crit Care Med 35:1999-2000, 2007.

Hostler D, Rittenberger JC, Roth R, Callaway CW:  Increased chest compression to ventilation ratio improves delivery of CPR. Resuscitation 74:446-452, 2007.

Stippler M, Fischer MR, Puccio AM, Wisniewski SR, Carson-Walter EB, Dixon CE, Walter KA:  Serum and cerebrospinal fluid magnesium in severe traumatic brain injury outcome.  J Neurotrauma 24:1347-1354, 2007.

Wagner AK, Postal BA, Darrah SD, Chen X, Khan AS: Deficits in novelty exploration after controlled cortical impact.  J Neurotrauma 24:1308-1320, 2007.

May/June/July 2007

Dixon CE, Kline AE. Neurotransmitters and electrophysiology in brain injury. In: Nervous System Dysfunction and Injury (Banik NL, Vol. Editor). Handbook of Neurochemistry and Molecular Neurobiology, Volume 24 Springer. (In press, 2007).

Kagan VE, Jiang J, Bayır H, Stoyanovsky DA:  Targeting nitroxides to mitochondria: location, location, location, and ...concentration Highlight Commentary on "Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: Role of mitochondrial superoxide"  Free Radic Biol Med 43(3):348-350, 2007.

Wagner AK, Kline AE, Ren D, Willard LA, Wenger MK, Zafonte RD, Dixon CE:  Gender associations with chronic methylphenidate treatment and behavioral performance following experimental traumatic brain injury.  Behav Brain Res 181(2):200-209.

Wagner AK, McElligott J, Chan L, Wagner EP 2nd, Segal NA, Gerber LH:   How gender impacts career development and leadership in rehabilitation medicine: a report from the AAPM&R research committee.  Arch Phys Med Rehabil 2007 May; 88(5):560-568.

Wagner AK, Ren D, Conley YP, Ma X, Kerr ME, Zafonte RD, Puccio AM, Marion DW, Dixon CE:  Sex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injury.  J Neurosurg 106(4):538-547, 2007.

March/April 2007

Bayır H, Kagan VE, Clark RSB, Janesko-Feldman K, Zhang X, Vagni V, Billiar TR, Kochanek PM:  Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury.  J Neurochem 101:168-181, 2007.

Cheng JP, Aslam HA, Hoffman AN, Zafonte RD, Kline AE:  The neurobehavioral benefit conferred by a single systemic administration of 8-OH-DPAT after brain trauma is confined to a narrow therapeutic window.  Neurosci Lett 416:165-8, 2007.

DeKosky ST, Abrahamson EE, Ciallella JR, Paljug WR, Wisniewski SR, Clark RS, Ikonomovic MD:  Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans. Arch Neurol Apr;64:541-544, 2007.

Dennis AM, Kochanek PM: Pathobiology of Blast Injury. Yearbook of Intensive Care and Emergency Medicine, J. L. Vincent (ed). Springer-Verlag, Berlin. pp. 1011-1022, 2007.. Springer-Verlag, Berlin. pp. 1011-1022, 2007.

Fink EL, Callaway CW, Tisherman SA, Kochanek PM:  Winning the cold war: Inroads into implementation of mild hypothermia after cardiac arrest in adults from the European Resuscitation Council Hypothermia After Cardiac Arrest Registry Study Group. Crit Care Med 35:1199-1202, 2007.

January/February 2007

Ho Y, Logue E, Callaway CW, Defranco DB: Different mechanisms account for extracellular-signal regulated kinase activation in distinct brain regions following global ischemia and reperfusion. Neuroscience 145:248-55, 2007.

Logue ES, McMichael MJ, Callaway CW:  Comparison of the effects of hypothermia at 33˚C or 35˚C after cardiac arrest in rats.  Acad Emerg Med 14:293-300, 2007.

Beers SR, Berger RP, Adelson PD: Outcomes; Neurocognitive Outcome and Serum Biomarkers in Inflicted versus Non-Inflicted Traumatic Brain Injury in Young Children. J Neurotrauma 24:97-105, 2007.

Clark RSB, Nathaniel PD, Zhang X, Dixon CE, Alber S, Watkins SC, Melick J, Kochanek PM, Graham SH: boc-Aspartyle(OMe)-Fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats. J Cereb Blood Flow Metab 27:316-326, 2007.

Drabek T, Stezoski J, Garman RH, Wu X, Tisherman SA, Stezoski SW, Fisk JA, Jenkins L, Kochanek PM: Emergency preservation and delayed resuscitation allows normal recovery after exsanguination cardiac arrest in rats: a feasibility trial. Crit Care Med 35:532-537, 2007. Accompanying editorial by Alam HB. To cool or not to cool, that is the question. Crit Care Med 35:660-662, 2007.

Gao W, Chadha MS, Berger RP, Omenn G, Allen D, Pisano M, Adelson PD, Clark RSB, Jenkins LW, Kochanek PM: Biomarkers and diagnosis: A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and non-inflicted pediatric traumatic brain injury. J Neurotrauma: 24:43-53, 2007.

Hostler D, Callaway CW, Newman DH, D'Cruz B: Thrombin-Antithrombin Appearance in Out-of-Hospital Cardiac Arrest. Prehosp Emerg Care 11:9-13, 2007.

Kentner R, Safar P, Behringer W, Wu X, Henchir J, Ma L, Hsia CJ, Tisherman SA:  Small volume resuscitation with tempol is detrimental during uncontrolled hemorrhagic shock in rats. Resuscitation 72:295-305, 2007.

Kline AE, Wagner AK, Westergom BP, Malena RR, Zafonte RD, Olsen AS, Sozda CN, Luthra P, Panda M, Cheng JP, Aslam HA:  Acute treatment with the 5-HT(1A) receptor agonist 8-OH-DPAT and chronic environmental enrichment confer neurobehavioral benefit after experimental brain trauma. Behav Brain Res 177:186-194, 2007.

Kline AE, Massucci JL, Zafonte RD, Dixon CE, Defeo JR, Rogers EH:  Differential effects of single versus multiple administrations of haloperidol and risperidone on functional outcome after experimental brain trauma.  Crit Care Med 35:919-924, 2007.

Kochanek PM, Berger RP, Margulies SS, Jenkins LW: Inflicted childhood neurotrauma: new insight into the detection, pathobiology, prevention, and treatment of our youngest patients with traumatic brain injury. J Neurotrauma 24:1-4, 2007.

Rittenberger JC, Menegazzi JJ, Callaway CW: Association of delay to first intervention with return of spontaneous circulation in a swine model of cardiac arrest.  Resuscitation 73:154-160, 2007.

Shore PM, Berger RP, Varma S, Janesko KL, Wisniewski SR, Clark RS, Adelson PD, Thomas NJ, Lai YC, Bayir H, Kochanek PM: Biomarkers and Diagnosis; Cerebrospinal Fluid Biomarkers versus Glasgow Coma Scale and Glasgow Outcome Scale in Pediatric Traumatic Brain Injury: The Role of Young Age and Inflicted Injury. J Neurotrauma 24:75-86, 2007.

Tyurina YY, Basova LV, Konduru NV, Tyurin VA, Potapovich AI, Cai P, Bayır H, Stoyanovsky D, Pitt BR, Shvedova AA, Fadeel B, Kagan VE: Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: Implications for the resolution of inflammation.  J Biol Chem 282:8498-8509, 2007.

Tyurin VA, Tyurina YY, Osipov AN, Belikova NA, Basova LV, Kapralov AA, Bayır H, Kagan VE. Interactions of cardiolipin and lyso-cardiolipins with cytochrome c and tBid: conflict or assistance in apoptosis. Cell Death Differ 14:872-875, 2007.

Yan HQ, Ma X, Chen X, Li Y, Shao L, Dixon CE: Delayed increase of tyrosine hydroxylase expression in rat nigrostriatal system after traumatic brain injury. Brain Res 1134:171-179, 2007.


 
 
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