Recent Publications

2009

Bales JW, Wagner AK, Kline AE, Dixon CE:  Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis.  Neurosci Biobehav Rev. 2009 Jul;33(7):981-1003.

Bayir H, Adelson PD, Wisniewski SR, Shore P, Lai Y, Brown D, Janesko-Feldman KL, Kagan VE, Kochanek PM: Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children. Crit Care Med. 2009 Feb;37(2):689-95. Erratum in: Crit Care Med. 2009 Apr;37(4):1536.

Bayir H, Kapralov AA, Jiang J, Huang Z, Tyurina YY, Tyurin VA, Zhao Q, Belikova NA, Vlasova II, Maeda A, Zhu J, Na HM, Mastroberardino PG, Sparvero LJ, Amoscato AA, Chu CT, Greenamyre JT, Kagan VE: Peroxidase mechanism of lipid dependent cross-linking of synuclein with cytochrome c: protection against apoptosis versus delayed oxidative stress in Parkinson's disease. J Biol Chem. 2009 Jun 5;284(23):15951-69.

Belikova NA, Jiang J, Stoyanovsky DA, Glumac A, Bayir H, Greenberger JS, Kagan VE: Mitochondria-targeted (2-hydroxyamino-vinyl)-triphenyl-phosphonium releases NO() and protects mouse embryonic cells against irradiation-induced apoptosis. FEBS Lett. 2009 Jun 18;583(12):1945-50

Bell MJ, Carpenter J, Au AK, Keating RF, Myseros JS, Yaun A, Weinstein S:  Development of a Pediatric Neurocritical Care Service. Neurocrit Care. 2009;10(1):4-10.

Berger RP, T’asan S, Rand A, Lokshin A, Kochanek P:   Multiplex assessment of serum biomarker concentrations in well-appearing children with inflicted traumatic brain injury.  Pediatr Res. 2009 Jan;65(1):97-102.

Berger R, Richichi R:  Derivation and validation of an equation for adjustment of neuron-specific enolase concentrations in hemolyzed serum.  Pediatr Crit Care Med. 2009 Mar;10(2):260-3.

Chu CT, Plowey ED, Dagda RK, Hickey RW, Cherra SJ 3rd, Clark RS: Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models. Methods Enzymol. 2009;453:217-49.

Dennis AM, Haselkorn ML, Vagni VA, Garman RH, Janesko-Feldman K, Bayir H, Clark RS, Jenkins LW, Dixon CE, Kochanek PM:  Hemorrhagic shock after experimental traumatic brain injury in mice: effect on neuronal death.  J Neurotrauma. 2009 Jun;26(6):889-99.

Dietrich WD, Bullock MR, Kochanek PM: Hypothermic therapies targeting brain and spinal cord injury. Introduction. J Neurotrauma. 2009 Mar;26(3):297-8.

Drabek T, Tisherman SA, Beuke L, Stezoski J, Janesko-Feldman K, Lahoud-Rahme M, Kochanek PM: Deep hypothermia attenuates microglial proliferation independent of neuronal death after prolonged cardiac arrest in rats. Anesth Analg. 2009 Sep;109(3):914-23

Du L, Hickey RW, Bayir H, Watkins SC, Tyurin VA, Guo F, Kochanek PM, Jenkins LW, Ren J, Gibson G, Chu CT, Kagan VE, Clark RS: Starving neurons show sex difference in autophagy. J Biol Chem. 2009 Jan 23;284(4):2383-96.

Exo J, Shellington D, Bayir H, Vagni V, Janesko KL, Ma L, Hsia CJ, Clark R, Jenkins LW, Dixon CE, Kochanek PM: Resuscitation of Traumatic Brain Injury and Hemorrhagic Shock with Polynitroxylated Albumin, Hextend, Hypertonic Saline and Lactated Ringers: Effects on Acute Hemodynamics, Survival, and Neuronal Death in Mice. J Neurotrauma. 2009 Aug 19. [Epub ahead of print]

Foley LM, Hitchens TK, Ho C, Janesko KL, Melick JA, Bayir H, Kochanek PM: Magnetic Resonance Imaging Assessment of Macrophage Accumulation in Mouse Brain after Experimental Traumatic Brain Injury. J Neurotrauma. 2009 Feb 18. [Epub ahead of print].

Hicks SD, Salcido DD, Logue ES, Suffoletto BP, Empey PE, Poloyac SM, Miller DR, Callaway CW, Menegazzi JJ:  Lipid Emulsion Combined with Epinephrine and Vasopressin Does Not Improve Survival in a Swine Model of Bupivacaine-induced Cardiac Arrest.  Anesthesiology. 2009 Jul;111(1):138-46.

Kagan VE, Bayir A, Bayir H, Stoyanovsky D, Borisenko GG, Tyurina YY, Wipf P, Atkinson J, Greenberger JS, Chapkin RS, Belikova NA: Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: a new strategy in anti-apoptotic drug discovery. Mol Nutr Food Res. 2009 Jan;53(1):104-14. Review.

Kagan VE, Bayir HA, Belikova NA, Kapralov O, Tyurina YY, Tyurin VA, Jiang J, Stoyanovsky DA, Wipf P, Kochanek PM, Greenberger JS, Pitt B, Shvedova AA, Borisenko G: Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. Free Radic Biol Med. 2009 Jun 1;46(11):1439-53.

Kampmeyer M, Callaway C:  Method of cold saline storage for prehospital induced hypothermia.  Prehosp Emerg Care. 2009 Jan-Mar;13(1):81-4

Kochanek PM, Tasker RC:  Pediatric neurointensive care: 2008 update for the Rogers' Textbook of Pediatric Intensive Care.  Pediatr Crit Care Med. 2009 Jul;10(4):517-23

Kochanek PM: Bakken Lecture: the brain, the heart, and therapeutic hypothermia. Cleve Clin J Med. 2009 Apr;76 Suppl 2:S8-12.

Kochanek PM, Bauman RA, Long J, Dixon CE, Jenkins LW:  A critical problem begging for new insight and new therapies.  J Neurotrauma. 2009 Jun;26(6):813-4.

Kochanek PM, Drabek T, Tisherman SA: Therapeutic hypothermia: the Safar vision. J Neurotrauma. 2009 Mar;26(3):417-20.

Kochanek PM, Fink EL, Bell MJ, Bayir H, Clark RS: Therapeutic hypothermia: applications in pediatric cardiac arrest. J Neurotrauma. 2009 Mar;26(3):421-7.

Konduru NV, Tyurina YY, Feng W, Basova LV, Belikova NA, Bayir H, Clark K, Rubin M, Stolz D, Vallhov H, Scheynius A, Witasp E, Fadeel B, Kichambare PD, Star A, Kisin ER, Murray AR, Shvedova AA, Kagan VE: Phosphatidylserine targets single-walled carbon nanotubes to professional phagocytes in vitro and in vivo. PLoS ONE. 2009;4(2):e4398.

Lahoud-Rahme MS, Stezoski J, Kochanek PM, Melick J, Tisherman SA, Drabek T: Blood-brain barrier integrity in a rat model of emergency preservation and resuscitation. Resuscitation. 2009 Apr;80(4):484-8.

Manole MD, Foley LM, Hitchens TK, Kochanek PM, Hickey RW, Bayır H, Alexander H, Ho C, Clark RS:  Magnetic resonance imaging assessment of regional cerebral blood flow after asphyxial cardiac arrest in immature rats.  J Cereb Blood Flow Metab. 2009 Jan;29(1):197-205.

Meert KL, Donaldson A, Nadkarni V, Tieves KS, Schleien CL, Brilli RJ, Clark RS, Shaffner DH, Levy F, Statler K, Dalton HJ, van der Jagt EW, Hackbarth R, Pretzlaff R, Hernan L, Dean JM, Moler FW; for the Pediatric Emergency Care Applied Research Network:  Multicenter cohort study of in-hospital pediatric cardiac arrest.  Pediatr Crit Care Med. 2009 May 15. [Epub ahead of print].

Moler FW, Meert K, Donaldson AE, Nadkarni V, Brilli RJ, Dalton HJ, Clark RS, Shaffner DH, Schleien CL, Statler K, Tieves KS, Hackbarth R, Pretzlaff R, van der Jagt EW, Levy F, Hernan L, Silverstein FS, Dean JM; for the Pediatric Emergency Care Applied Research Network:  In-hospital versus out-of-hospital pediatric cardiac arrest: A multicenter cohort study.  Crit Care Med. 2009 Jul;37(7):2259-67.

Mumma BE, Shellenbarger D, Callaway CW, Katz KD, Guyette FX, Rittenberger JC: Neurologic recovery following cardiac arrest due to carbon monoxide poisoning. Resuscitation. 2009 Jul;80(7):835.

Ochalski PG, Okonkwo DO, Bell MJ, Adelson PD: Reversal of sedation with flumazenil in a child after traumatic brain injury. J Neurosurg Pediatr. 2009 Mar;3(3):240-3.

Puccio AM, Hoffman LA, Bayir H, Zullo TG, Michael FR, Darby JM, Alexander SA, Dixon CE, Okonkwo DO, Kochanek PM:  Effect of short periods of normobaric hyperoxia on local brain tissue oxygenation and cerebrospinal fluid oxidative stress markers in severe traumatic brain injury.  J Neurotrauma. 2009 Jun 8. [Epub ahead of print].

Reynolds JC, Callaway CW, El Khoudary SR, Moore CG, Alvarez RJ, Rittenberger JC: Review of A Large Clinical Series: Coronary Angiography Predicts Improved Outcome Following Cardiac Arrest: Propensity-adjusted Analysis. J Intensive Care Med. 2009 May-Jun;24(3):179-86.

Rittenberger JC, Callaway CW: Transport of Patients After Out-of-Hospital Cardiac Arrest: Closest Facility or Most Appropriate Facility? Ann Emerg Med. 2009 Aug;54(2):256-7

Sanchez de Toledo J, Adelson PD, Watson RS, Gaines B, Brown SD, Kochanek PM, Wisniewski SR, Fink E, Bayır H, Clark RS, Bell MJ: Relationship Between Increases in Pancreatic Enzymes and Cerebral Events in Children After Traumatic Brain Injury. Neurocrit Care. 2009 Aug 11. [Epub ahead of print]

Shvedova AA, Kagan VE: Phosphatidylserine targets single-walled carbon nanotubes to professional phagocytes in vitro and in vivo. PLoS ONE. 2009;4(2):e4398

Tortorici MA, Mu Y, Kochanek PM, Xie W, Poloyac SM: Moderate hypothermia prevents cardiac arrest-mediated suppression of drug metabolism and induction of interleukin-6 in rats. Crit Care Med. 2009 Jan;37(1):263-9.

Tyurin VA, Tyurina YY, Jung MY, Tungekar MA, Wasserloos KJ, Bayır H, Greenberger JS, Kochanek PM, Shvedova AA, Pitt B, Kagan VE: Mass-spectrometric analysis of hydroperoxy- and hydroxy-derivatives of cardiolipin and phosphatidylserine in cells and tissues induced by pro-apoptotic and pro-inflammatory stimuli. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2863-72.

Wagner AK, Drewencki LL, Chen X, Santos FR, Khan AS, Harun R, Torres GE, Michael AC, Dixon CE: Chronic methylphenidate treatment enhances striatal dopamine neurotransmission after experimental traumatic brain injury. J Neurochem. 2009 Feb;108(4):986-97.

Wagner AK, Sokoloski JE, Chen X, Harun R, Clossin DP, Khan AS, Andes-Koback M, Michael AC, Dixon CE:  Controlled Cortical Impact Injury Influences Methylphenidate Induced Changes In Striatal Dopamine Neurotransmission.  J Neurochem. 2009 Aug;110(3):801-10.



2008

Ahmad M, Rose ME, Vagni V, Griffith RP, Dixon CE, Kochanek PM, Hickey RW, Graham SH:  Genetic disruption of cyclooxygenase-2 does not improve histological or behavioral outcome after traumatic brain injury in mice.  J Neurosci Res. 2008 Dec;86(16):3605-12.

Au AK, Ray PE, McBryde KD, Newman KD, Weinstein SL, Bell MJ:  Incidence of postoperative hyponatremia and complications in critically-ill children treated with hypotonic and normotonic solutions.  J Pediatr 152:33-38, 2008.

Bayır H, Kagan VE:  Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis - there is nothing more practical than a good theory. Crit Care 12:206, 2008.

Bell MJ, Kochanek PM: Traumatic brain injury in children: recent advances in management. Indian J Pediatr. 2008 Nov;75(11):1159-65.

Bell MJ, Carpenter J, Au AK, Keating RF, Myseros JS, Yaun A, Weinstein S:  Development of a Pediatric Neurocritical Care Service. Neurocrit Care 2008 Feb 7. [Epub ahead of print].

Berger RP, T’asan S, Rand A, Lokshin A, Kochanek P:   Multiplex assessment of serum biomarker concentrations in well-appearing children with inflicted traumatic brain injury.  Pediatr Res 2008 Sep 10. [Epub ahead of print]

Berger RP, Richichi R:  Derivation and validation of an equation for adjustment of neuron-specific enolase concentrations in hemolyzed serum.  Pediatr Crit Care Med (in press).

Betz AE, Callaway CW, Hostler D, Rittenberger JC: Work of CPR during two different compression to ventilation ratios with real-time feedback. Resuscitation. 2008 Nov;79(2):278-82.

Callaway CW:  Why does the sensitivity of computed tomographic scan for detecting subarachnoid blood never improve? Ann Emerg Med 2008; 51:705-706.

Callaway CW, Ramos R, Logue ES, Betz AE, Wheeler M, Repine MJ: Brain-derived neurotrophic factor does not improve recovery after cardiac arrest in rats. Neurosci Lett. 2008 Nov 7;445(1):103-7.

Cheng JP, Hoffman AN, Zafonte RD, Kline AE: A delayed and chronic treatment regimen with the 5-HT(1A) receptor agonist 8-OH-DPAT after cortical impact injury facilitates motor recovery and acquisition of spatial learning.  Behav Brain Res 194:79-85, 2008.

Clark RS, Bayır H, Chu CT, Alber SM, Kochanek PM, Watkins SC:  Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness. Autophagy 4:88-90, 2008.

Crane SA, Callaway CW, Milbrandt EB, Huang DT:  Rethinking bystander CPR for out-of-hospital cardiac arrest. Crit Care 12:302, 2008.

Drabek T, Han F, Garman RH, Stezoski J, Tisherman SA, Stezoski SW, Morhard RC, Kochanek PM:  Assessment of the delta opioid agonist DADLE in a rat model of lethal hemorrhage treated by emergency preservation and resuscitation.  Resuscitation 77:220-228, 2008.

Drabek T, Kochanek PM:  In quest of the optimal cooling device: isn’t faster “too fast”? Crit Care Med 36:1018-1020, 2008.

Fink EL, Lai Y, Zhang X, Janesko-Feldman K, Adelson PD, Szabó C, Berger RP, Sarnaik AA, Kochanek PM, Clark RS:  Quantification of poly(ADP-ribose)-modified proteins in cerebrospinal fluid from infants and children after traumatic brain injury. J Cereb Blood Flow Metab 28:1523-1529, 2008.

Foley LM, Hitchens TK, Melick JA, Bayır H, Ho C, Kochanek PM:  Effect of inducible nitric oxide synthase on cerebral blood flow after experimental traumatic brain injury in mice.  J Neurotrauma 25:299-310, 2008.

Han F, Drabek T, Stezoski J, Janesko-Feldman K, Stezoski SW, Clark RS, Bayır H, Tisherman SA, Kochanek PM:  Protein nitration and poly-ADP-ribosylation in brain after rapid exsanguination cardiac arrest in a rat model of emergency preservation and resuscitation.  Resuscitation. 2008 Nov;79(2):301-10.

Hartman M, Watson RS, Linde-Zwirble W, Clermont G, Weissfeld L, Lave JR, Kochanek P, Angus D:  Pediatric traumatic brain injury is inconsistently regionalized in the US.  Pediatrics 122(1):e172-80, 2008.

Hoffman AN, Malena RR, Westergom BP, Luthra P, Cheng JP, Aslam HA, Zafonte RD, Kline AE: Environmental enrichment-mediated functional improvement after experimental traumatic brain injury is contingent on task-specific neurobehavioral experience.  Neurosci Lett 431:226-230, 2008. 

Hoffman AN, Cheng JP, Zafonte RD, Kline AE:  Administration of haloperidol and risperidone after neurobehavioral testing hinders the recovery of traumatic brain injury-induced deficits. Life Sci 83:602-607, 2008.

Hsu AA, Fenton K, Weinstein S, Carpenter J, Dalton H, Bell MJ:  Neurological injury markers in children with septic shock. Pediatr Crit Care Med 9:245-251, 2008.

Kline AE, Hoffman AN, Cheng JP, Zafonte RD, Massucci JL: Chronic administration of antipsychotics impede behavioral recovery after experimental traumatic brain injury. Neurosci Lett. 2008 Dec 31;448(3):263-7.

Kochanek PM, Berger RP, Bayr H, Wagner AK, Jenkins LW, Clark RS:  Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making.  Curr Opin Crit Care 14:135-141, 2008.

Kochanek PM, Bell MJ, Adelson PD:  Hypothermia therapy after traumatic brain injury in children.  N Engl J Med 359:1179; author reply 1180, 2008.

Lai Y, Hickey RW, Chen Y, Bayır H, Sullivan ML, Chu CT, Kochanek PM, Dixon CE, Jenkins LW, Graham SH, Watkins SC, Clark RS:  Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester.  J Cereb Blood Flow Metab 28:540-550, 2008.

Lai Y, Chen Y, Watkins SC, Nathaniel PD, Guo F, Kochanek PM, Jenkins LW, Szabo C, Clark RS:  Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury.  J Neurochem 104:1700-1711, 2008.

Majerske CW, Mihalik JP, Ren D, Collins MW, Reddy CC, Lovell MR, Wagner AK:  Concussion in sports: postconcussive activity levels, symptoms, and neurocognitive performance. J Athl Train  43:265-274, 2008.

Manole MD, Hickey RW, Clark RS, Kochanek PM:  Current and future therapies of pediatric cardiopulmonary arrest.  Indian J Pediatr  75:609-614, 2008.

Moore TM, Callaway CW, Hostler D:  Core temperature cooling in healthy volunteers after rapid intravenous infusion of cold and room temperature saline solution.  Ann Emerg Med 51:153-159, 2008.

Neumar RW, Nolan JP, Adrie C, Aibiki M, Berg RA, Böttiger BW, Callaway C, Clark RS, Geocadin RG, Jauch EC, Kern KB, Laurent I, Longstreth WT Jr, Merchant RM, Morley P, Morrison LJ, Nadkarni V, Peberdy MA, Rivers EP, Rodriguez-Nunez A, Sellke FW, Spaulding C, Sunde K, Vanden Hoek T: Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation. 2008 Dec 2;118(23):2452-83.

Nichol G, Thomas E, Callaway CW, Hedges J, Powell JL, Aufderheide TP, Rea T, Lowe R, Brown T, Dreyer J, Davis D, Idris A, Stiell I; Resuscitation Outcomes Consortium Investigators: Regional variation in out-of-hospital cardiac arrest incidence and outcome. JAMA. 2008 Sep 24;300(12):1423-31. Erratum in: JAMA. 2008 Oct 15;300(15):1763.

Nolan JP, Neumar RW, Adrie C, Aibiki M, Berg RA, Böttiger BW, Callaway C, Clark RS, Geocadin RG, Jauch EC, Kern KB, Laurent I, Longstreth WT, Merchant RM, Morley P, Morrison LJ, Nadkarni V, Peberdy MA, Rivers EP, Rodriguez-Nunez A, Sellke FW, Spaulding C, Sunde K, Hoek TV: Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A Scientific Statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke. Resuscitation. 2008 Dec;79(3):350-79.

Raina KD, Callaway C, Rittenberger JC, Holm MB: Neurological and functional status following cardiac arrest: method and tool utility. Resuscitation. 2008 Nov;79(2):249-56.

Rittenberger JC, Hostler DP, Tobin T, Gaines J, Callaway CW:  Predictors of ROSC in witnessed aeromedical cardiac arrests.  Resuscitation 76:43-64, 2008

Rittenberger JC, Guyette FX, Tisherman SA, DeVita MA, Alvarez RJ, Callaway CW: Outcomes of a hospital-wide plan to improve care of comatose survivors of cardiac arrest. Resuscitation. 2008 Nov;79(2):198-204.

Sarnaik AA, Conley YP, Clark RS: Susceptibility to meningococcal infection--nature versus nurture? Pediatr Crit Care Med. 2008 Sep;9(5):540-2.

Sharangpani A, Takanohashi A, Bell MJ:  Caspase activation in fetal rat brain following experimental intrauterine inflammation. Brain Res 1200C:138-145, 2008.

Tehranian R, Rose ME, Vagni V, Pickrell AM, Griffith RP, Liu H, Clark RSB, Dixon CE, Kochanek PM, Graham SH:  Disruption of Bax Protein Prevents Neuronal Cell Death but Produces Cognitive Impairment in Mice following Traumatic Brain Injury. J Neurotrauma 25:755-767, 2008.

Tisherman SA, Bokhari F, Collier B, Cumming J, Ebert J, Holevar M, Kurek S, Leon S, Rhee P:  Clinical practice guideline: penetrating zone II neck trauma. J Trauma 64:1392-405, 2008.

Tyurin VA, Tyurina YY, Feng W, Mnuskin A, Jiang J, Tang M, Zhang X, Zhao Q, Kochanek PM, Clark RS, Bayir H, Kagan VE: Mass-spectrometric characterization of phospholipids and their primary peroxidation products in rat cortical neurons during staurosporine-induced apoptosis. J Neurochem. 2008 Dec;107(6):1614-33.

Tyurin VA, Tyurina YY, Kochanek PM, Hamilton R, DeKosky ST, Greenberger JS, Bayır H, Kagan VE:  Oxidative lipidomics of programmed cell death.  Methods Enzymol 442:375-393, 2008.

Wu X, Drabek T, Tisherman SA, Henchir J, Stezoski SW, Culver S, Stezoski J, Jackson EK, Garman R, Kochanek PM:  Emergency preservation and resuscitation with profound hypothermia, oxygen, and glucose allows reliable neurological recovery after 3 h of cardiac arrest from rapid exsanguination in dogs. J Cereb Blood Flow Metab 28:302-311, 2008.



2007

Bayır H, Kagan VE, Clark RSB, Janesko-Feldman K, Zhang X, Vagni V, Billiar TR, Kochanek PM:  Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury.  J Neurochem 101:168-181, 2007.

Bayır H, Tyurin VA, Tyurina YY, Viner R, Ritov V, Amoscato AA, Zhao Q, Zhang XJ, Janesko-Feldman KL, Alexander H, Basova LV, Clark RS, Kochanek PM, Kagan VE: Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis.  Ann Neurol 62:154-169, 2007.

Beers SR, Berger RP, Adelson PD: Outcomes; Neurocognitive Outcome and Serum Biomarkers in Inflicted versus Non-Inflicted Traumatic Brain Injury in Young Children. J Neurotrauma 24:97-105, 2007.

Berger RP, Beers SR, Richichi R, Wiesman D, Adelson PD:  Serum biomarker concentrations and outcome after pediatric traumatic brain injury.  J Neurotrauma 24:1793-1801, 2007.

Buttram SD, Wisniewski SR, Jackson EK, Adelson PD, Feldman K, Bayir H, Berger RP, Clark RS, Kochanek PMMultiplex assessment of cytokine and chemokine levels in cerebrospinal fluid following severe pediatric traumatic brain injury: Effects of moderate hypothermia. J Neurotrauma 24:1707-1718, 2007.

Cao G, Xing J, Xiao X, Liou AK, Gao Y, Yin XM, Clark RS, Graham SH, Chen J:  Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury.  Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury.  J Neurosci 27:9278-9293, 2007.

Cheng JP, Aslam HA, Hoffman AN, Zafonte RD, Kline AE:  The neurobehavioral benefit conferred by a single systemic administration of 8-OH-DPAT after brain trauma is confined to a narrow therapeutic window.  Neurosci Lett 416:165-8, 2007.

Clark RSB, Nathaniel PD, Zhang X, Dixon CE, Alber S, Watkins SC, Melick J, Kochanek PM, Graham SH: boc-Aspartyle(OMe)-Fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats. J Cereb Blood Flow Metab 27:316-326, 2007.

Clark RS, Vagni VA, Nathaniel PD, Jenkins LW, Dixon CE, Szabo C:  Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice.  J Neurotrauma 24:1399-1405, 2007.

DeKosky ST, Abrahamson EE, Ciallella JR, Paljug WR, Wisniewski SR, Clark RS, Ikonomovic MD:  Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans. Arch Neurol Apr;64:541-544, 2007.

Dennis AM, Kochanek PM: Pathobiology of Blast Injury. Yearbook of Intensive Care and Emergency Medicine, J. L. Vincent (ed). Springer-Verlag, Berlin. pp. 1011-1022, 2007.. Springer-Verlag, Berlin. pp. 1011-1022, 2007.

Dixon CE, Kline AE. Neurotransmitters and electrophysiology in brain injury. In: Nervous System Dysfunction and Injury (Banik NL, Vol. Editor). Handbook of Neurochemistry and Molecular Neurobiology, Volume 24 Springer. (In press, 2007).

Drabek T, Fisk JA, Dixon CE, Garman RH, Stezoski J, Wisniewski SR, Wu X, Tisherman SA, Kochanek PM:  Prolonged deep hypothermic circulatory arrest in rats can be achieved without cognitive deficit.  Life Sci 81:543-552, 2007.

Drabek T, Stezoski J, Garman RH, Wu X, Tisherman SA, Stezoski SW, Fisk JA, Jenkins L, Kochanek PM: Emergency preservation and delayed resuscitation allows normal recovery after exsanguination cardiac arrest in rats: a feasibility trial. Crit Care Med 35:532-537, 2007. Accompanying editorial by Alam HB. To cool or not to cool, that is the question. Crit Care Med 35:660-662, 2007.

Drabek T, Stezoski J, Garman RH, Han F, Henchir J, Tisherman SA, Stezoski SW, Kochanek PM:  Exsanguination cardiac arrest in rats treated by 60 min, but not 75 min, emergency preservation and delayed resuscitation is associated with intact outcome. Resuscitation 75:114-123, 2007.

Fink EL, Callaway CW, Tisherman SA, Kochanek PM:  Winning the cold war: Inroads into implementation of mild hypothermia after cardiac arrest in adults from the European Resuscitation Council Hypothermia After Cardiac Arrest Registry Study Group. Crit Care Med 35:1199-1202, 2007.

Fink EL, Callaway CW, Tisherman SA, Kochanek PM:  Hypothermia in traumatic brain injury.  Crit Care Med 35:1999-2000, 2007.

Gao W, Chadha MS, Berger RP, Omenn G, Allen D, Pisano M, Adelson PD, Clark RSB, Jenkins LW, Kochanek PM: Biomarkers and diagnosis: A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and non-inflicted pediatric traumatic brain injury. J Neurotrauma: 24:43-53, 2007.

Ho Y, Logue E, Callaway CW, Defranco DB: Different mechanisms account for extracellular-signal regulated kinase activation in distinct brain regions following global ischemia and reperfusion. Neuroscience 145:248-55, 2007.

Hostler D, Callaway CW, Newman DH, D'Cruz B: Thrombin-Antithrombin Appearance in Out-of-Hospital Cardiac Arrest. Prehosp Emerg Care 11:9-13, 2007.

Hostler D, Rittenberger JC, Roth R, Callaway CW:  Increased chest compression to ventilation ratio improves delivery of CPR. Resuscitation 74:446-452, 2007.

Janata A, Bayegan K, Weihs W, Schratter A, Holzer M, Frossard M, Sipos W, Springler G, Schmidt P, Sterz F, Losert UM, Laggner AN, Kochanek PM, Behringer W:  Emergency preservation and resuscitation improve survival after 15 minutes of normovolemic cardiac arrest in pigs.  Crit Care Med 35:2785-2791, 2007.

Kagan VE, Jiang J, Bayır H, Stoyanovsky DA:  Targeting nitroxides to mitochondria: location, location, location, and …concentration: highlight commentary on "Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide".  Free Radic Biol Med 43:348-350, 2007.

Kagan VE, Jiang J, Bayır H, Stoyanovsky DA:  Targeting nitroxides to mitochondria: location, location, location, and ...concentration Highlight Commentary on "Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: Role of mitochondrial superoxide"  Free Radic Biol Med 43(3):348-350, 2007.

Kapralov AA, Kurnikov IV, Vlasova II, Belikova NA, Tyurin VA, Basova LV, Zhao Q, Tyurina YY, Jiang J, Bayır H, Vladimirov YA, Kagan VE:  The Hierarchy of structural transitions induced in cytochrome c by anionic phospholipids determines its peroxidase activation and selective peroxidation during apoptosis in cells.  Biochemistry 46:14232-14244, 2007.

Kentner R, Safar P, Behringer W, Wu X, Henchir J, Ma L, Hsia CJ, Tisherman SA:  Small volume resuscitation with tempol is detrimental during uncontrolled hemorrhagic shock in rats. Resuscitation 72:295-305, 2007.

Kline AE, Wagner AK, Westergom BP, Malena RR, Zafonte RD, Olsen AS, Sozda CN, Luthra P, Panda M, Cheng JP, Aslam HA:  Acute treatment with the 5-HT(1A) receptor agonist 8-OH-DPAT and chronic environmental enrichment confer neurobehavioral benefit after experimental brain trauma. Behav Brain Res 177:186-194, 2007.

Kline AE, Massucci JL, Zafonte RD, Dixon CE, Defeo JR, Rogers EH:  Differential effects of single versus multiple administrations of haloperidol and risperidone on functional outcome after experimental brain trauma.  Crit Care Med 35:919-924, 2007.

Kochanek PM, Berger RP, Margulies SS, Jenkins LW: Inflicted childhood neurotrauma: new insight into the detection, pathobiology, prevention, and treatment of our youngest patients with traumatic brain injury. J Neurotrauma 24:1-4, 2007.

Lo BM, Quinn SM, Hostler D, Callaway CW:  Rescue shock outcomes during out-of-hospital cardiac arrest.  Resuscitation 75:469-475, 2007.

Logue ES, McMichael MJ, Callaway CW:  Comparison of the effects of hypothermia at 33˚C or 35˚C after cardiac arrest in rats.  Acad Emerg Med 14:293-300, 2007.

Rittenberger JC, Menegazzi JJ, Callaway CW: Association of delay to first intervention with return of spontaneous circulation in a swine model of cardiac arrest.  Resuscitation 73:154-160, 2007.

Shore PM, Berger RP, Varma S, Janesko KL, Wisniewski SR, Clark RS, Adelson PD, Thomas NJ, Lai YC, Bayir H, Kochanek PM: Biomarkers and Diagnosis; Cerebrospinal Fluid Biomarkers versus Glasgow Coma Scale and Glasgow Outcome Scale in Pediatric Traumatic Brain Injury: The Role of Young Age and Inflicted Injury. J Neurotrauma 24:75-86, 2007.

Stippler M, Fischer MR, Puccio AM, Wisniewski SR, Carson-Walter EB, Dixon CE, Walter KA:  Serum and cerebrospinal fluid magnesium in severe traumatic brain injury outcome.  J Neurotrauma 24:1347-1354, 2007.

Tortorici MA, Kochanek PM, Poloyac SM:  Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system.  Crit Care Med 35:2196-2204, 2007. Review.

Tyurina YY, Basova LV, Konduru NV, Tyurin VA, Potapovich AI, Cai P, Bayır H, Stoyanovsky D, Pitt BR, Shvedova AA, Fadeel B, Kagan VE: Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: Implications for the resolution of inflammation.  J Biol Chem 282:8498-8509, 2007.

Tyurin VA, Tyurina YY, Osipov AN, Belikova NA, Basova LV, Kapralov AA, Bayır H, Kagan VE. Interactions of cardiolipin and lyso-cardiolipins with cytochrome c and tBid: conflict or assistance in apoptosis. Cell Death Differ 14:872-875, 2007.

Venneti S, Wagner AK, Wang G, Slagel SL, Chen X, Lopresti BJ, Mathis CA, Wiley CA:  The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging.  Exp Neurol 207:118-127, 2007.

Wagner AK, McElligott J, Chan L, Wagner EP 2nd, Segal NA, Gerber LH:   How gender impacts career development and leadership in rehabilitation medicine: a report from the AAPM&R research committee.  Arch Phys Med Rehabil 2007 May; 88(5):560-568.

Wagner AK, Kline AE, Ren D, Willard LA, Wenger MK, Zafonte RD, Dixon CE:  Gender associations with chronic methylphenidate treatment and behavioral performance following experimental traumatic brain injury.  Behav Brain Res 181(2):200-209.

Wagner AK, Ren D, Conley YP, Ma X, Kerr ME, Zafonte RD, Puccio AM, Marion DW, Dixon CE:  Sex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injury.  J Neurosurg 106(4):538-547, 2007.

Wagner AK, Postal BA, Darrah SD, Chen X, Khan AS: Deficits in novelty exploration after controlled cortical impact.  J Neurotrauma 24:1308-1320, 2007.

Yan HQ, Ma X, Chen X, Li Y, Shao L, Dixon CE: Delayed increase of tyrosine hydroxylase expression in rat nigrostriatal system after traumatic brain injury. Brain Res 1134:171-179, 2007.

 


 
 
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