NIH Directors Clayton and Collins Cite Work of Safar Center Scientists to Support Gender Balance in Animal Studies

A recent commentary in the journal Nature debuted new NIH policies to fund preclinical research that addresses the disparity between studies that use males, and studies that use females. The commentary specifically cited the article, “Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway,” which represented a highly cited manuscript published in 2004 in the Journal of Biological Chemistry by Drs. Bayir and Clark, among other Safar Center researchers.  The findings in that report were unique in that they revealed innate gender differences, specifically, in that study neuronal death pathways were importantly different between female and male neurons examined in culture this suggested the potential need for gender based studies even in cell culture.