2007 Neurointensive Care and Resuscitation Research Journal Club

Date

Presenters

Title

12/21/2007

Robert Hickey, MD

In vivo and in vitro Characterization of a Novel Neuroprotective Strategy for Stroke: Ischemic Postconditioning

 

Bob Garman, DVM

Translating Developmental Time Across Mammalian Species.

 

Mioara Manole, MD

Hyperoxide Reperfusion after Global Ischemia Decreases Hippocampal Energy Metabolism.

12/7/2007

Empey

Change in Pharmacokinetics of Model Compounds with Different Elimination Processes in Rats during Hypothermia.

 

Dave Shellington, MD

Essential Protective Roles of Reactive Astrocytes in Traumatic Brain Injury.

 

Hoffman

Nicotinamide treatment Reduces Behavioral Impairments and Provides Cortical Protection after Fluid Percussion Injury in the Rat

11/30/2007

James Bales, MD

Neurotrophin-Mediated Neuroprotection of Hippocampal Neurons Following    Traumatic Brain Injury is Not Associated with Acute Recovery of Hippocampal Function.

 

Dave Shellington, MD; Empey

Microglia Induce Neurotoxicity via Intraneural ZN2+ Release and a K+ Current Surge.

11/9/2007

Patrick Kochanek, MD

A trial of therapeutic hypothermia via endovascular approach in awake patients with acute ischemic stroke:  Methodology.

 

Mioara Manole, MD

A nitric oxide donor reduces brain injury and enhances recovery of cerebral blood flow after hypoxia-ischemia in the newborn rat.

10/19/2007

Anthony Kline, PhD

Chronic Cognitive Deficits and Long-Term Histopathological Alterations following Contusive Brain Injury in the Immature Rat.

 

Ying Mu, MD, PhD

Successful cardiopulmonary resuscitation after cardiac arrest as a "sepsis-like" syndrome.

10/12/2007

Jennifer Exo, MD

Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage.

 

Ajit Sarnaik, MD

In situ localization of P-glycoprotein (ABCB1) in human and rat brain.

10/05/2007

James Bales, MD

Epigenetic modulation of seizure-induced neurogenesis and cognitive decline.

 

Bob Clark, MD

Ketamine-induced neuronal cell death in the perinatal rhesus monkey.

9/28/2007

Hülya Bayır, MD

Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia.

 

Craig Smith, MD

Transvascular delivery of small interfering RNA to the central nervous system.

 

Martina Stippler, MD

Biomarkers and diagnosis; protein biomarkers in serum of pediatric patients with severe traumatic brain injury identified by ICAT-LC-MS/MS.

9/21/2007

Karen Walson, MD

Attenuation of oxidative injury after induction of experimental intracerebral hemorrhage in heme oxygenase-2 knockout mice.

 

Bob Garman, DVM

Dual role of intrauterine immune challenge on neonatal and adult brain vulnerability to hypoxia-ischemia.

9/14/2007

Jocelyn Zhou, PhD

Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance.

 

Hülya Bayır, MD

Saline or albumin for fluid resuscitation in patients with traumatic brain injury.

8/31/2007

Martina Stippler, MD

TRPMs and neuronal cell death.

 

Dave Shellington, MD

Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia.

8/24/2007

Dave Shellington, M.D.

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration.

 

Minke Tang, M.D.

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.

8/17/2007

Bob Garman, D.V.M.

Perisomatic thalamic axotomy after diffuse traumatic brain injury is associated with atrophy rather than cell death.

 

Mike Bell, M.D.

Selective vulnerability of preterm white matter to oxidative damage defined by F2-isoprostanes.

8/10/2007

Craig Smith, M.D.

Use of opioids in asphyxiated term neonates: effects on neuroimaging and clinical outcome.

 

Mioara Manole, M.D.

Polynitroxyl albumin reduces infarct size in transient focal cerebral ischemia in the rat: potential mechanisms studied by magnetic resonance imaging.

 

Ericka Fink, M.D.

Erythropoietin protects from post-traumatic edema in the rat brain.

8/3/2007

Megan Miller

Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele.

 

Bob Clark, M.D.

Increased pentose phosphate pathway flux after clinical traumatic brain injury: a [1,2-(13)C(2)]glucose labeling study in humans.

 

Dave Shellington, M.D.

The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: Implications for PET imaging.

7/27/2007

Martina Stippler, M.D.

Tryptophan metabolism and oxidative stress in patients with chronic brain injury.

 

Sheila Alexander, Ph.D.

Long-lasting regeneration after ischemia in the cerebral cortex.

 

Karen Walson, M.D.

Haptoglobin and the development of cerebral artery vasospasm after subarachnoid hemorrhage.

7/20/2007

Anthony Kline, Ph.D.

The Novel Apolipoprotein E-Based Peptide COG1410 Improves Sensorimotor Performance and Reduces Injury Magnitude following Cortical Contusion Injury.

 

Ajit Sarnaik, M.D.

Neuroprotective effect of erythropoietin, and role of metallothionein-1 and -2, in permanent focal cerebral ischemia.

7/6/2007

Bob Garman, DVM

Bilateral changes after neonatal ischemia in the P7 rat brain.

 

Martina Stippler, M.D.

Acute metabolic brain changes following traumatic brain injury and their relevance to clinical severity and outcome.

 

Sheila Alexander, Ph.D.

Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1

6/29/2007

Brett Postal

Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury

 

Jocelyn Zhou, Ph.D.

In Vivo Activation of Human Pregnane X Receptor Tightens the Blood-Brain Barrier to Methadone through P-Glycoprotein Up-Regulation

 

Sam Poloyac, Ph.D.

Role of drug efflux carriers in the healthy and diseased brain.

6/7/2007

Craig Smith, M.D.

Inhibition of caspase-mediated apoptosis by peroxynitrite in traumatic brain injury.

 

Patrick M. Kochanek, M.D.

Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism.

5/11/2007

Minke Tang, M.D.

Evidence of a protective effect of phosphatidylserine-containing liposomes on lipopolysaccharide-induced impairment of long-term potentiation in the rat hippocampus.

 

Martina Stippler, M.D.

Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial.

4/27/2007

Rachel Berger, M.D.

Diffusion Tensor Imaging in the Corpus Callosum in Children after Moderate to Severe Traumatic Brain Injury.

 

Amy Wagner, M.D.

Detection of Traumatic Axonal Injury with Diffusion Tensor Imaging in a Mouse Model of Traumatic Brain Injury.

 

Joelle Scanlon, M.D.

Principles of Diffusion Tensor Imaging and its Applications to Basic Neuroscience Research.

4/20/2007

Craig Smith, M.D.

Minocycline Attenuates Hypoxia-Ischemia-Induced Neurological Dysfunction and Brain Injury in the Juvenile Rat.

 

Ajit Sarnaik, M.D.

Naloxone and Epinephrine are Equally Effective for Cardiopulmonary Resuscitation in a Rat Asphyxia Model.

 

Patrick M. Kochanek, M.D.

Opposed Effects of Hypertonic Saline on Contusions and Noncontused Brain Tissue in Patients with Severe Traumatic Brain Injury.

4/11/2007

Ericka Fink, M.D.

Clinical Application of Mild Therapeutic Hypothermia after Cardiac Arrest.

 

Bob Clark, M.D.

Rapamycin is a Neuroprotective Treatment for Traumatic Brain Injury.

 

Larry Jenkins, Ph.D.

Regulation of Neuronal PKA Signaling through AKAP Targeting Dynamics.

4/6/2007

Tomas Drabek, M.D.

Cardiopulmonary Resuscitation Bystanders with Chest Compression only (SOS-KANTO):  An Observational Study.

 

Mioara Manole, M.D.

Acute Cerebral Blood Flow Variations after Human Cardiac Arrest Assessed by Stable Xenon Enhanced Computed Tomography.

 

Ajit Sarnaik, M.D.

Effects of Hypertonic Arginine on Cerebral Blood Flow and Intracranial Pressure after Traumatic Brain Injury Combined with Hemorrhagic Hypotension.

3/7/2007

Sheila Alexander, Ph.D.

Temporal Changes in Cerebral Tissue Oxygenation with Cerebrovascular Pressure Reactivity in Severe Traumatic Brain Injury.

 

Tomas Drabek, M.D.

A Comparison of Electrically Induced Cardiac Arrest with Cardiac Produced by Coronary Occlusion.

 

Hülya Bayır, M.D.

Apoptosis-Inducing Factor is a Major Contributor to Neuronal Loss Induced by Neonatal Cerebral Hypoxia-Ischemia.

2/23/2007

David Shellington, M.D.

White Matter Plasticity and Enhanced Remyelination in the Maternal CNS.

 

Minke Tang, M.D.

Apoptotic PC12 Cells Exposing Phosphatidylserine Promote the Production of Anti-Inflammatory and Neuroprotective Molecules by Microglial Cells.

 

Robert Hickey, M.D.

Endoplasmic Reticulum Stress Inhibition Protects Against Excitotoxic Neuronal Injury in the Rat Brain.

2/2/2007

Anthony Kline, Ph.D.

Embryonic Stem Cell Transplantation after Experimental Traumatic Brain Injury Dramatically Improves Neurological Outcome, but may cause Tumors.

 

Sheila Alexander, Ph.D.

Hyperventilation Following Head Injury:  Effect on Ischemic Burden and Cerebral Oxidative Metabolism.

 

Tomas Drabek, M.D.

Hydrogen Sulfide Attenuates Lipopolysaccharide-Induced Inflammation by Inhibition of p38 Mitogen-Activated Protein Kinase in Microglia.

1/26/2007

Bob Garman, D.V.M.

Dopaminergic Substantia Nigra Neurons Project Topographically Organized to the Subventricular Zone and Stimulate Precursor Cell Proliferation in Aged Primates.

 

Larry Jenkins, Ph.D.

The Artic Ground Squirrel Brain is Resistant to Injury from Cardiac Arrest during Euthermia.

 

Patrick M. Kochanek, M.D.

Intracranial Pressure Complicating Severe Traumatic Brain Injury in Children: Monitoring and Management.

1/19/2007

Peiying Chuang, M.D.

Neuroglobin-Overexpressing Transgenic Mice are Resistant to Cerebral and Myocardial Ischemia.

 

Mioara Manole, M.D.

Protective Effects of Combined Superoxide Dismutase and Deferoxamine on Recovery of Cerebral Blood Flow and Function After Cardiac Arrest in Dogs.

 

Amy Wagner, M.D.

Thalamic and Hippocampal Mechanisms in Spatial Navigation:  A Dissociation between Brain Mechanisms for Learning how Versus Learning Where to Navigate.

1/12/2007

Karen Walson, M.D.

Modulation of the Oxidative Stress and Inflammatory Response by PPA-γ Agonists in the Hippocampus of Rats Exposed to Cerebral Ischemia/Reperfusion.

 

Alia Dennis, M.D.

Traumatic Brain Injury Attenuates the Effectiveness of Lactated Ringer’s Solution Resuscitation of Hemorrhagic Shock in Rats.

 

Sheila Alexander, Ph.D.

Analysis of the XRCCI Gene as a Modifier of the Cerebral Response in Ischemic Stroke.

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