2006
Neurointensive Care and Resuscitation Research Journal Club |
Date |
Presenters |
Title |
12/22/2006 |
Ajit Sarnaik, M.D. |
Erythropoietin Enhances Neurogenesis and Restores Spatial Memory in Rats after Traumatic Brain Injury. |
|
Mioara Manole, M.D. |
Differential Effect of PARP-2 Deletion on Brain Injury after Focal and Global Cerebral Ischemia. |
|
Hong Yan, M.D. |
The Neurobiology of Dopamine Signaling. |
12/08/2006 |
Anthony Kline, Ph.D. |
Working Memory Training Decreases Hippocampal Neurogenesis. |
|
Alia Dennis, M.D. |
Predominant Phagocytic Activity of Resident Microglia over Hematogenous Macrophages Following Transient Focal Cerebral Ischemia: An Investigation using Green Fluorescent Protein Transgenic Bone Marrow Chimeric Mice. |
|
Bob Garman, D.V.M. |
The Fate of Nissl-Stained Dark Neurons Following Traumatic Brain Injury in Rats: Difference between Neocortex and Hippocampus Regarding Survival Rate. |
12/01/2006 |
Mioara Manole, M.D. |
Posttraumatic Hyperemia in Immature, Mature, and Aged Rats: Autoradiographic Determination of Cerebral Blood Flow. |
|
Ericka Fink, M.D. |
Genetic Influences on Outcome Following Acute Neurological Insults. |
|
Hülya Bayır, M.D. |
Traumatic Injury to the Immature Brain Results in Progressive Neuronal Loss, Hyperactivity and Delayed Cognitive Impairments. |
11/17/2006 |
Bob Garman, D.V.M. |
Neuroprotective Cannabinoid Receptor Antagonist SR141716A Prevents Downregulation of Excitotoxic NMDA Receptors in the Ischemic Penumbra. |
|
Anthony Kline, Ph.D. |
Alterations in Spatial Learning and Memory after Forced Exercise. |
|
Sheila Alexander, Ph.D. |
Decreased Expression of Glutamate Transporters in Astrocytes after Human Traumatic Brain Injury. |
11/10/2006 |
Xiangbai Chen, M.D. |
Increasing CNS Morepinephrine Levels by the Precursor L-DOPS Facilitate Beam-Walking Recovery after Sensorimotor Cortex Ablation in Rats. |
|
Hülya Bayır, M.D. |
Brain Neuroprotection by Scavenging Blood Glutamate. |
|
Patrick M. Kochanek, MD |
Mitochondrial Uncoupling Protein-2 Protects the Immature Brain from Excitotoxic Neuronal Death. |
11/03/2006 |
Alia Dennis, M.D. |
Enhanced Expression of Iba1, Ionized Calcium-Binding Adapter Molecule 1, after Transient Focal Cerebral Ischemia in Rat Brain. |
|
Mioara Manole, M.D. |
Neuronal Damage in Rat Brain and Spinal Cord after Cardiac Arrest and Massive Hemorrhagic Shock. |
|
Amy Wagner, M.D. |
Enhanced Catecholamine Synthesis in the Prefrontal Cortex after Traumatic Brain Injury: Implications for Prefrontal Dysfunction. |
10/27/2006 |
Martina Stippler, M.D |
Conventional Neurocritical Care and Cerebral Oxygenation after Traumatic Brain Injury. |
|
Craig Smith, M.D. |
Deletion of the c-Jun N-Terminal Kinase 3 Gene Protects Neonatal Mice against Cerebral Hypoxic-Ischemic Injury. |
|
Ericka Fink, M.D. |
Consequential Apoptosis in the Cerebellum Following Injury to the Developing Rat Forebrain. |
10/20/2066 |
Bob Hickey, M.D. |
Cerebral Ischemia-Hypoxia Induces Intravascular Coagulation and Autophagy. |
|
Bob Garman, D.V.M. |
Opiod Preconditioning Induces Opioid Receptor-Dependent Delayed Neuroprotection against Ischemia in Rats. |
|
Hülya Bayır, M.D. |
Mitochondrial Oxidative Damage and Dysfunction in a Mouse Model of Focal Traumatic Brain Injury: Implications for Neuroprotective Therapy. |
10/13/2006 |
Sam Poloyac, Ph.D. |
Brain Trauma Leads to Enhanced Lung Inflammation and Injury: Evidence for Role of P4504Fs in Resolution. |
|
Larry Jenkins, Ph.D. |
Alterations in Mammalian Target of Rapamycin Signaling Pathways after Traumatic Brain Injury. |
10/6/2006 |
Hong Yan, M.D. |
Reversal of Brain Injury-Induced Prefrontal Glutamic Acid Decarboxylase Expression and Working Memory Deficits by D1 Receptor Antagonism. |
|
Martina Stippler, M.D. |
ProTECT: Randomized Clinical Trial of Progressive for Acute Traumatic Brain Injury. |
|
Mioara Manole, M.D. |
The Role of Neuronal Signaling in Controlling Cerebral Blood Flow. |
9/29/2006 |
Hülya Bayır, M.D |
Neuroprotection by Selective Inhibition of Inducible Nitric Oxide Synthase after Experimental Brain Contusion. |
| |
Mioara Manole, M.D. |
Cerebral Ischemia: The No Reflow Phenomenon. |
| |
Patrick M. Kochanek, M.D. |
Multidrug Resistance in Epilepsy: Rats with drug-Resistant Seizures Exhibit Enhanced Brain Expression of P-Glycoprotein Compared with Rats with Drug-Responsive Seizures. |
9/22/2006 |
Alia Dennis, M.D. |
Blast-Induced Neurotrauma in Whales. |
|
Bob Garman, D.V.M. |
Evidence of Apoptosis in the Subventricular Zone and Rostral Migratory Stream in the MPTP Mouse Model of Parkinson Disease. |
|
Patrick M. Kochanek, M.D.. |
Adenosine A1 Receptors are Crucial in Keeping an Epileptic Focus Localized. |
9/15/2006 |
Martina Stippler, M.D. |
Levetiracetam is Neuroprotective in Murine Models of Closed Head Injury and Subarachnoid Hemorrhage. |
|
Ajit Sarnaik, M.D. |
Effect of Intracranial Pressure Monitoring and Targeted Intensive Care on Functional Outcome after Severe Head Injury. |
|
Bob Clark, M.D. |
In Vivo Imaging of Apoptosis in Patients with Acute Stroke: Correlation with Blood-Brain Barrier Permeability. |
9/8/2006 |
Mioara Manole, M.D. |
Increased Cortical Cerebral Blood Flow by Continuous Infusion of Adrenaline (Epinephrine) during Experimental Cardiopulmonary Resuscitation. |
| |
Bob Garman, D.V.M. |
Normoxic Resuscitation after Cardiac Arrest Protects against Hippocampal Oxidative Stress, Metabolic Dysfunction, and Neuronal Death. |
| |
Anthony Kline, Ph.D. |
Delayed, Post-Injury Treatment with Aniracetam Improves Cognitive Performance after Traumatic Brain Injury in Rats. |
9/1/2006 |
Ashley Kochanek |
Translational Control by CPEB: The Cytoplasmic Polyadenylation Element Binding Protein Modulation, Migration, and Memory. |
| |
Glenn Gobbel, Ph.D. |
Less Neurogenesis and Inflammation in the Immature than in the Juvenile Brain after Cerebral Hypoxia-Ischemia. |
| |
Martina Stippler, M.D. |
Exercise Pre-Conditioning Strengthens Brain Microvascular Integrity in a Rat Stroke Model. |
7/28/2006 |
Mioara Manole, M.D. |
Time Course of Circulatory and Metabolic Recovery of Cat Brain after Cardiac Arrest Assessed by Perfusion- and Diffusion-Weighted Imaging MR-Spectroscopy. |
|
Xiangbai Chen, M.D. |
Recovery after Damage to Motor Cortical Areas. |
|
Mike Hilton |
Is oxygen Supply a Limiting Factor for Survival during Rewarming from Profound Hypothermia. |
6/30/2006 |
Martina Stippler, M.D. |
Alteration in Brain Natriuretic Peptide (BNP) Plasma Concentration Following Severe Traumatic Brain Injury. |
|
Ericka Fink, M.D. |
Evaluation of Spatial Working Memory Function in Children and Adults with Fetal Alcohol Spectrum Disorders: A Functional Magnetic Resonance Imaging Study. |
|
Bob Garman, D.V.M. |
The Return of the Dark Neuron. A Histological Artifact Complicating Contemporary Neurotoxicologic Evaluation. |
6/23/2006 |
Ericka Fink, M.D |
Prognostic Value of 1H-MRS in Neonatal Encephalopathy. |
| |
James Bales |
Adenosine A2A Receptor Gene Expression in the Normal Striatum and after 6-OH-Dopamine Lesion. |
| |
Jerry Chuang |
The Effects of Combined Fluid Percussion Traumatic Brain Injury and Unilateral Entorhinal Deafferentation on the Juvenile Rat Brain. |
6/16/2006 |
Xiangbai Chen, M.D. |
Noradrenaline Transporter Blockers Raise Extracellular Dopamine in Medial Prefrontal but not Parietal and Occipital cortex: Differences with Mianserin and Clozapine. |
| |
Sheila Alexander, Ph.D. |
Intensive Insulin Therapy Reduces Microdialysis Glucose Values without Altering Glucose Utilization or Improving the Lactate/Pyruvate Ratio Traumatic Brain Injury. |
| |
Larry Jenkins, Ph.D. |
Cerebral Energy Metabolism, Glucose Transport and Blood Flow: Changes with Maturation and Adaptation to Hypoglycaemia. |
6/09/2006 |
Alia Dennis, M.D. |
Glutamate Antagonism During Secondary Deafferentation Enhances Cognition and Axo-Dendritic Integrity after Traumatic Brain Injury. |
|
Bob Hickey, M.D. |
Loss of Autophagy in the Central Nervous System Causes Neurodegeneration in Mice. |
|
Xiangbai Chen, M.D. |
Noradrenaline Transporter Blockers Raise Extracellular Dopamine in Medial Prefrontal but not Parietal and Occipital cortex: Differences with Mianserin and Clozapine. |
6/02/2006 |
Ericka Fink, M.D. |
Hippocampal Neurogenesis is not Required for Behavioral Effects of Environmental Enrichment. |
|
Hülya Bayır, M.D. |
Synaptogenesis in the Hippocampal CA1 Field Following Traumatic Brain Injury. |
|
Patrick M. Kochanek, M.D. |
Isoflurane Preconditioning Induces Neuroprotection that is Inducible Nitric Oxide Synthase-Dependent in Neonatal Rats. |
5/26/2006 |
Mike Tortorici, Pharm.D. |
Genetic Variation in Soluble Epoxide Hydrolase (EPHX2) and Risk of Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study. |
|
Anthony Kline, Ph.D. |
Differential Effects of Delta9 -THC on Learning in Adolescent and Adult Rats. |
|
Hülya Bayır, M.D. |
Why Does Acute Hyperglycemia Worsen the Outcome of Transient Focal Cerebral Ischemia? |
5/12/2006 |
Alia Dennis, M.D. |
Acute, Transient Hemorrhagic Hypotension does not Aggravate Structural Damage or Neurologic Motor Deficits but Delays the Long-Term Cognitive Recovery Following Mild to Moderate Traumatic Brain Injury. |
|
Bob Garman, D.V.M. |
Purkinje Cell Vulnerability to Mild and Severe Forebrain Head Trauma. |
|
Mioara Manole, M.D. |
Comparison of 30 and the 100% Inspired Oxygen Concentrations during Early Post-Resuscitation Period: A Randomized Controlled Pilot Study. |
5/05/2006 |
Larry Jenkins, Ph.D. |
The Protean Actions of Neurotrophins and Their Receptors on the Life and Death of Neurons. |
|
Patrick M.Kochanek, M.D. |
Resuscitation with a Hemoglobin-Based Oxygen Carrier after Traumatic Brain Injury. |
4/28/2006 |
Hülya Bayır, M.D. |
Role of Matrix Metalloproteinases in Delayed Cortical Responses after Stroke. |
|
Bob Garman, D.V.M. |
High Plasma Cyst(e)ine Level May Indicate Poor Clinical Outcome in Patients with Acute Stroke: Possible Involvement of Hydrogen Sulfide. |
|
Ericka Fink, M.D. |
Growth Hormone is Produced within the Hippocampus where it Responds to Age, Sex, and Stress. |
4/21/2006 |
Yi-Chen Lai, M.D. |
Induction of Mild Hypothermia with Infusion of Cold (4ºC) Fluid during Ongoing Experimental CPR. |
|
Lina Du, M.D. |
Biphasic Cytochrome C Release after Transient Global Ischemia and its Inhibition by Hypothermia. |
4/07/2006 |
Alia Dennis, M.D. |
Reduced Mortality Rate in Patients with Severe Traumatic Brain Injury Treated with Brain Tissue Oxygen Monitoring. |
|
Hülya Bayır, M.D. |
Mitochondrial Lipid Abnormality and Electron Transport Chain Impairment in Mice Lacking α-Synuclein. |
|
Bob Clark, M.D. |
PolyADP-Ribosylation is Involved in Neurotrophic Activity. |
3/29/2006 |
Bob Garman, D.V.M. |
High Level of Adenosine A1 Receptor-Like Immunoreactivity in the CA2/CA3 Region of the Adult Rat Hippocampus. |
|
Anthony Kline, Ph.D. |
Chronic Nicotine Improves Working and Reference Memory Performance and Reduces Hippocampal NGF in Aged Female Rats. |
|
Yi-Chen Lai, M.D. |
Cerebral Oxygenation and Electrical Activity After Birth Asphyxia: Their Relation to Outcome. |
3/24/2006 |
Tomas Drabek, M.D. |
Hippocampus BCL-2 and Bax Expression and Neuronal Apoptosis after Moderate Hypothermic Cardiopulmonary Bypass in Rats. |
|
Ericka Fink, M.D. |
Gene Transfer of Hepatocyte Growth Factor Gene Improves Learning and Memory in the Chronic Stage of Cerebral Infarction. |
|
Sheila Alexander, Ph.D. |
Activity in the Peri-Infarct Rim in Relation to Recovery from Stroke. |
3/17/2006 |
Anthony Kline, Ph.D. |
Lateral Fluid Percussion Injury in the Developing Rat Causes an Acute, Mild Behavioral Dysfunction in the Absence of Significant Cell Death. |
|
Yi-Chen Lai, M.D. |
Nitric Oxide-Dependent Negative Feedback of Parp-1 Transactivation of the iNOS Gene. |
|
Hülya Bayır, M.D. |
Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis. |
3/10/2006 |
Mioara Manole, M.D. |
Spontaneous Gasping Decreases Intracranial Pressure and Improves Cerebral Perfusion in a Pig Model of Ventricular Fibrillation. |
|
Larry Jenkins, Ph.D. |
Endoplasmic Reticulum Stress: Cell Life and Death Decisions. |
|
Patrick M. Kochanek, M.D. |
In Situ Labeling of Immune Cells with Iron Oxide Particles: An Approach to Detect Organ Rejection by Cellular MRI. |
3/3/2006 |
Sheila Alexander |
NXY-059 for Acute Ischemic Stroke. |
|
Bob Hickey, M.D. |
Sodium 4-Phenylbutyrate Protects against Cerebral Ischemic Injury. |
|
Tomas Drabek, M.D. |
Epinephrine Increases Mortality after Brief Asphyxial Cardiac Arrest in an In Vitro Rat Model. |
2/24/06 |
Larry Jenkins, Ph.D. |
Neurological Bases of Behavioral Development in Infancy. |
|
Yi-Chen Lai, M.D. |
The Developing Nervous System: A Series of Review Articles. |
|
Bob Garman, D.V.M. |
KCC2 Expression in Immature Rat Cortical Neurons is Sufficient to Switch the Polarity of GABA Responses. |
2/10/06 |
Lina Du, M.D. |
SOD1 overexpression and Female Sex Exhibit Region-Specific Neuroprotection after Global Cerebral Ischemia Due to Cardiac Arrest. |
|
Yi-Chen Lai, M.D. |
Reduced Mortality Rate in Patients with Severe Traumatic Brain Injury Treated with Brain Tissue Oxygen Monitoring. |
|
Larry Jenkins, Ph.D. |
Neurological Bases of Behavioral Development in Infancy. |
2/03/06 |
Ericka Fink, M.D. |
Organizational Effects of Early Gonadal Secretions on Sexual Differentiation in Spatial Memory. |
|
Tomas Drabek, M.D. |
Retrograde Cerebral Perfusion of Oxygenated, Compacted Red Blood Cells Attenuates Brain Damage after Hypothermia Circulation Arrest of Rat. |
|
Patrick M. Kochanek, M.D. |
Cerebral Blood Flow Thresholds for mRNA Synthesis after Focal Ischemia and the Effect of MK-801. |
1/27/06 |
Ericka Fink, M.D. |
Cortisol Levels and Adrenal Reserve after Successful Cardiac Arrest Resuscitation. |
|
Fei Han, M.D. |
Ischemic Preconditioning or Heat Shock Pretreatment Ameliorates Neuronal Apoptosis Following Hypothermic Circulatory Arrest. |
|
Bob Garman, D.V.M. |
Subventricular Zone Neuroblasts Emigrate Toward Cortical Lesions. |
1/20/06 |
Yi-Chen Lai, M.D. |
NMDA Receptors are Expressed in Oligodendrocytes and Activated in Ischaemia. |
|
Hülya Bayır, M.D. |
A Novel Method to Determine Specificity and Sensitivity of the TUNEL Reaction in the Quantitation of Apoptosis. |
|
Hülya Bayır, M.D. |
Intravenously Administered Propidium Iodide Labels Necrotic Cells in the Intact Mouse Brain After Injury. |
1/13/06 |
Hong Yan, M.D. |
Delayed Hypothermia Preferentially Increases Expression of Brain-Derived Neurotrophic Factor Exon III in Rat Hippocampus after Asphyxial Cardiac Arrest. |
|
Anthony Kline, Ph.D. |
Electrical Stimulation of the Vagus Nerve Enhances Cognitive and Motor Recovery following Moderate Fluid Percussion Injury in the Rat. |
|
Xiangbei Chen, M.D. |
The protective effect of nebivovol on ischemia/reperfusion injury in rabbit spinal cord. |
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