2006 Neurointensive Care and Resuscitation Research Journal Club

Date

Presenters

Title

12/22/2006

Ajit Sarnaik, M.D.

Erythropoietin Enhances Neurogenesis and Restores Spatial Memory in Rats after Traumatic Brain Injury.

 

Mioara Manole, M.D.

Differential Effect of PARP-2 Deletion on Brain Injury after Focal and Global Cerebral Ischemia.

 

Hong Yan, M.D.

The Neurobiology of Dopamine Signaling.

12/08/2006

Anthony Kline, Ph.D.

Working Memory Training Decreases Hippocampal Neurogenesis.

 

Alia Dennis, M.D.

Predominant Phagocytic Activity of Resident Microglia over Hematogenous Macrophages Following Transient Focal Cerebral Ischemia:  An Investigation using Green Fluorescent Protein Transgenic Bone Marrow Chimeric Mice.

 

Bob Garman, D.V.M.

The Fate of Nissl-Stained Dark Neurons Following Traumatic Brain Injury in Rats:  Difference between Neocortex and Hippocampus Regarding Survival Rate.

12/01/2006

Mioara Manole, M.D.

Posttraumatic Hyperemia in Immature, Mature, and Aged Rats:  Autoradiographic Determination of Cerebral Blood Flow.

 

Ericka Fink, M.D.

Genetic Influences on Outcome Following Acute Neurological Insults.

 

Hülya Bayır, M.D.

Traumatic Injury to the Immature Brain Results in Progressive Neuronal Loss, Hyperactivity and Delayed Cognitive Impairments.

11/17/2006

Bob Garman, D.V.M.

Neuroprotective Cannabinoid Receptor Antagonist SR141716A Prevents Downregulation of Excitotoxic NMDA Receptors in the Ischemic Penumbra.

 

Anthony Kline, Ph.D.

Alterations in Spatial Learning and Memory after Forced Exercise.

 

Sheila Alexander, Ph.D.

Decreased Expression of Glutamate Transporters in Astrocytes after Human Traumatic Brain Injury.

11/10/2006

Xiangbai Chen, M.D.

Increasing CNS Morepinephrine Levels by the Precursor L-DOPS Facilitate Beam-Walking Recovery after Sensorimotor Cortex Ablation in Rats.

 

Hülya Bayır, M.D.

Brain Neuroprotection by Scavenging Blood Glutamate.

 

Patrick M. Kochanek, MD

Mitochondrial Uncoupling Protein-2 Protects the Immature Brain from Excitotoxic Neuronal Death.

11/03/2006

Alia Dennis, M.D.

Enhanced Expression of Iba1, Ionized Calcium-Binding Adapter Molecule 1, after Transient Focal Cerebral Ischemia in Rat Brain.

 

Mioara Manole, M.D.

Neuronal Damage in Rat Brain and Spinal Cord after Cardiac Arrest and Massive Hemorrhagic Shock.

 

Amy Wagner, M.D.

Enhanced Catecholamine Synthesis in the Prefrontal Cortex after Traumatic Brain Injury:  Implications for Prefrontal Dysfunction.

10/27/2006

Martina Stippler, M.D

Conventional Neurocritical Care and Cerebral Oxygenation after Traumatic Brain Injury.

 

Craig Smith, M.D.

Deletion of the c-Jun N-Terminal Kinase 3 Gene Protects Neonatal Mice against Cerebral Hypoxic-Ischemic Injury.

 

Ericka Fink, M.D.

Consequential Apoptosis in the Cerebellum Following Injury to the Developing Rat Forebrain.

10/20/2066

Bob Hickey, M.D.

Cerebral Ischemia-Hypoxia Induces Intravascular Coagulation and Autophagy.

 

Bob Garman, D.V.M.

Opiod Preconditioning Induces Opioid Receptor-Dependent Delayed Neuroprotection against Ischemia in Rats.

 

Hülya Bayır, M.D.

Mitochondrial Oxidative Damage and Dysfunction in a Mouse Model of Focal Traumatic Brain Injury:  Implications for Neuroprotective Therapy.

10/13/2006

Sam Poloyac, Ph.D.

Brain Trauma Leads to Enhanced Lung Inflammation and Injury: Evidence for Role of P4504Fs in Resolution.

 

Larry Jenkins, Ph.D.

Alterations in Mammalian Target of Rapamycin Signaling Pathways after Traumatic Brain Injury.

10/6/2006

Hong Yan, M.D.

Reversal of Brain Injury-Induced Prefrontal Glutamic Acid Decarboxylase Expression and Working Memory Deficits by D1 Receptor Antagonism.

 

Martina Stippler, M.D.

ProTECT:  Randomized Clinical Trial of Progressive for Acute Traumatic Brain Injury.

 

Mioara Manole, M.D.

The Role of Neuronal Signaling in Controlling Cerebral Blood Flow.

9/29/2006

Hülya Bayır, M.D

Neuroprotection by Selective Inhibition of Inducible Nitric Oxide Synthase after Experimental Brain Contusion.

 

Mioara Manole, M.D.

Cerebral Ischemia:  The No Reflow Phenomenon.

 

Patrick M. Kochanek, M.D.

Multidrug Resistance in Epilepsy:  Rats with drug-Resistant Seizures Exhibit Enhanced Brain Expression of P-Glycoprotein Compared with Rats with Drug-Responsive Seizures.

9/22/2006

Alia Dennis, M.D.

Blast-Induced Neurotrauma in Whales.

 

Bob Garman, D.V.M.

Evidence of Apoptosis in the Subventricular Zone and Rostral Migratory Stream in the MPTP Mouse Model of Parkinson Disease.

 

Patrick M. Kochanek, M.D..

Adenosine A1 Receptors are Crucial in Keeping an Epileptic Focus Localized.

9/15/2006

Martina Stippler, M.D.

Levetiracetam is Neuroprotective in Murine Models of Closed Head Injury and Subarachnoid Hemorrhage.

 

Ajit Sarnaik, M.D.

Effect of Intracranial Pressure Monitoring and Targeted Intensive Care on Functional Outcome after Severe Head Injury.

 

Bob Clark, M.D.

In Vivo Imaging of Apoptosis in Patients with Acute Stroke:  Correlation with Blood-Brain Barrier Permeability.

9/8/2006

Mioara Manole, M.D.

Increased Cortical Cerebral Blood Flow by Continuous Infusion of Adrenaline (Epinephrine) during Experimental Cardiopulmonary Resuscitation.

 

Bob Garman, D.V.M.

Normoxic Resuscitation after Cardiac Arrest Protects against Hippocampal Oxidative Stress, Metabolic Dysfunction, and Neuronal Death.

 

Anthony Kline, Ph.D.

Delayed, Post-Injury Treatment with Aniracetam Improves Cognitive Performance after Traumatic Brain Injury in Rats.

9/1/2006

Ashley Kochanek

Translational Control by CPEB: The Cytoplasmic Polyadenylation Element Binding Protein Modulation, Migration, and Memory.

 

Glenn Gobbel, Ph.D.

Less Neurogenesis and Inflammation in the Immature than in the Juvenile Brain after Cerebral Hypoxia-Ischemia.

 

Martina Stippler, M.D.

Exercise Pre-Conditioning Strengthens Brain Microvascular Integrity in a Rat Stroke Model.

7/28/2006

Mioara Manole, M.D.

Time Course of Circulatory and Metabolic Recovery of Cat Brain after Cardiac Arrest Assessed by Perfusion- and Diffusion-Weighted Imaging MR-Spectroscopy.

 

Xiangbai Chen, M.D.

Recovery after Damage to Motor Cortical Areas.

 

Mike Hilton

Is oxygen Supply a Limiting Factor for Survival during Rewarming from Profound Hypothermia.

6/30/2006

Martina Stippler, M.D.

Alteration in Brain Natriuretic Peptide (BNP) Plasma Concentration Following Severe Traumatic Brain Injury.

 

Ericka Fink, M.D.

Evaluation of Spatial Working Memory Function in Children and Adults with Fetal Alcohol Spectrum Disorders: A Functional Magnetic Resonance Imaging Study.

 

Bob Garman, D.V.M.

The Return of the Dark Neuron. A Histological Artifact Complicating Contemporary Neurotoxicologic Evaluation.

6/23/2006

Ericka Fink, M.D

Prognostic Value of 1H-MRS in Neonatal Encephalopathy.

 

James Bales

Adenosine A2A Receptor Gene Expression in the Normal Striatum and after 6-OH-Dopamine Lesion.

 

Jerry Chuang

The Effects of Combined Fluid Percussion Traumatic Brain Injury and Unilateral Entorhinal Deafferentation on the Juvenile Rat Brain.

6/16/2006

Xiangbai Chen, M.D.

Noradrenaline Transporter Blockers Raise Extracellular Dopamine in Medial Prefrontal but not Parietal and Occipital cortex:  Differences with Mianserin and Clozapine.

 

Sheila Alexander, Ph.D.

Intensive Insulin Therapy Reduces Microdialysis Glucose Values without Altering Glucose Utilization or Improving the Lactate/Pyruvate Ratio Traumatic Brain Injury.

 

Larry Jenkins, Ph.D.

Cerebral Energy Metabolism, Glucose Transport and Blood Flow:  Changes with Maturation and Adaptation to Hypoglycaemia.

6/09/2006

Alia Dennis, M.D.

Glutamate Antagonism During Secondary Deafferentation Enhances Cognition and Axo-Dendritic Integrity after Traumatic Brain Injury.

 

Bob Hickey, M.D.

Loss of Autophagy in the Central Nervous System Causes Neurodegeneration in Mice.

 

Xiangbai Chen, M.D.

Noradrenaline Transporter Blockers Raise Extracellular Dopamine in Medial Prefrontal but not Parietal and Occipital cortex:  Differences with Mianserin and Clozapine.

6/02/2006

Ericka Fink, M.D.

Hippocampal Neurogenesis is not Required for Behavioral Effects of Environmental Enrichment.

 

Hülya Bayır, M.D.

Synaptogenesis in the Hippocampal CA1 Field Following Traumatic Brain Injury.

 

Patrick M. Kochanek, M.D.

Isoflurane Preconditioning Induces Neuroprotection that is Inducible Nitric Oxide Synthase-Dependent in Neonatal Rats.

5/26/2006

Mike Tortorici, Pharm.D.

Genetic Variation in Soluble Epoxide Hydrolase (EPHX2) and Risk of Coronary Heart Disease:  The Atherosclerosis Risk in Communities (ARIC) Study.

 

Anthony Kline, Ph.D.

Differential Effects of Delta9 -THC on Learning in Adolescent and Adult Rats.

 

Hülya Bayır, M.D.

Why Does Acute Hyperglycemia Worsen the Outcome of Transient Focal Cerebral Ischemia?

5/12/2006

Alia Dennis, M.D.

Acute, Transient Hemorrhagic Hypotension does not Aggravate Structural Damage or Neurologic Motor Deficits but Delays the Long-Term Cognitive Recovery Following Mild to Moderate Traumatic Brain Injury.

 

Bob Garman, D.V.M.

Purkinje Cell Vulnerability to Mild and Severe Forebrain Head Trauma.

 

Mioara Manole, M.D.

Comparison of 30 and the 100% Inspired Oxygen Concentrations during Early Post-Resuscitation Period:  A Randomized Controlled Pilot Study.

5/05/2006

Larry Jenkins, Ph.D.

The Protean Actions of Neurotrophins and Their Receptors on the Life and Death of Neurons.

 

Patrick M.Kochanek, M.D.

Resuscitation with a Hemoglobin-Based Oxygen Carrier after Traumatic Brain Injury.

4/28/2006

Hülya Bayır, M.D.

Role of Matrix Metalloproteinases in Delayed Cortical Responses after Stroke.

 

Bob Garman, D.V.M.

High Plasma Cyst(e)ine Level May Indicate Poor Clinical Outcome in Patients with Acute Stroke:  Possible Involvement of Hydrogen Sulfide.

 

Ericka Fink, M.D.

Growth Hormone is Produced within the Hippocampus where it Responds to Age, Sex, and Stress.

4/21/2006

Yi-Chen Lai, M.D.

Induction of Mild Hypothermia with Infusion of Cold (4ºC) Fluid during Ongoing Experimental CPR.

 

Lina Du, M.D.

Biphasic Cytochrome C Release after Transient Global Ischemia and its Inhibition by Hypothermia.

4/07/2006

Alia Dennis, M.D.

Reduced Mortality Rate in Patients with Severe Traumatic Brain Injury Treated with Brain Tissue Oxygen Monitoring.

 

Hülya Bayır, M.D.

Mitochondrial Lipid Abnormality and Electron Transport Chain Impairment in Mice Lacking α-Synuclein.

 

Bob Clark, M.D.

PolyADP-Ribosylation is Involved in Neurotrophic Activity.

3/29/2006

Bob Garman, D.V.M.

High Level of Adenosine A1 Receptor-Like Immunoreactivity in the CA2/CA3 Region of the Adult Rat Hippocampus.

 

Anthony Kline, Ph.D.

Chronic Nicotine Improves Working and Reference Memory Performance and Reduces Hippocampal NGF in Aged Female Rats.

 

Yi-Chen Lai, M.D.

Cerebral Oxygenation and Electrical Activity After Birth Asphyxia:  Their Relation to Outcome.

3/24/2006

Tomas Drabek, M.D.

Hippocampus BCL-2 and Bax Expression and Neuronal Apoptosis after Moderate Hypothermic Cardiopulmonary Bypass in Rats.

 

Ericka Fink, M.D.

Gene Transfer of Hepatocyte Growth Factor Gene Improves Learning and Memory in the Chronic Stage of Cerebral Infarction.

 

Sheila Alexander, Ph.D.

Activity in the Peri-Infarct Rim in Relation to Recovery from Stroke.

3/17/2006

Anthony Kline, Ph.D. 

Lateral Fluid Percussion Injury in the Developing Rat Causes an Acute, Mild Behavioral Dysfunction in the Absence of Significant Cell Death.

 

Yi-Chen Lai, M.D.

Nitric Oxide-Dependent Negative Feedback of Parp-1 Transactivation of the iNOS Gene.

 

Hülya Bayır, M.D. 

Caspases 3 and 7:  Key Mediators of Mitochondrial Events of Apoptosis.

3/10/2006

Mioara Manole, M.D. 

Spontaneous Gasping Decreases Intracranial Pressure and Improves Cerebral Perfusion in a Pig Model of Ventricular Fibrillation.

 

Larry Jenkins, Ph.D.

Endoplasmic Reticulum Stress:  Cell Life and Death Decisions.

 

Patrick M. Kochanek, M.D.

In Situ Labeling of Immune Cells with Iron Oxide Particles:  An Approach to Detect Organ Rejection by Cellular MRI.

3/3/2006

Sheila Alexander

NXY-059 for Acute Ischemic Stroke.

 

Bob Hickey, M.D.

Sodium 4-Phenylbutyrate Protects against Cerebral Ischemic Injury.

 

Tomas Drabek, M.D.

Epinephrine Increases Mortality after Brief Asphyxial Cardiac Arrest in an In Vitro Rat Model.

2/24/06

Larry Jenkins, Ph.D.

Neurological Bases of Behavioral Development in Infancy.

 

Yi-Chen Lai, M.D.

The Developing Nervous System:  A Series of Review Articles.

 

Bob Garman, D.V.M.

KCC2 Expression in Immature Rat Cortical Neurons is Sufficient to Switch the Polarity of GABA Responses.

2/10/06

Lina Du, M.D.

SOD1 overexpression and Female Sex Exhibit Region-Specific Neuroprotection after Global Cerebral Ischemia Due to Cardiac Arrest.

 

Yi-Chen Lai, M.D.

Reduced Mortality Rate in Patients with Severe Traumatic Brain Injury Treated with Brain Tissue Oxygen Monitoring.

 

Larry Jenkins, Ph.D.

Neurological Bases of Behavioral Development in Infancy.

2/03/06

Ericka Fink, M.D.

Organizational Effects of Early Gonadal Secretions on Sexual Differentiation in Spatial Memory.

 

Tomas Drabek, M.D.

Retrograde Cerebral Perfusion of Oxygenated, Compacted Red Blood Cells Attenuates Brain Damage after Hypothermia Circulation Arrest of Rat.

 

Patrick M. Kochanek, M.D.

Cerebral Blood Flow Thresholds for mRNA Synthesis after Focal Ischemia and the Effect of MK-801.

1/27/06

Ericka Fink, M.D.

Cortisol Levels and Adrenal Reserve after Successful Cardiac Arrest Resuscitation.

 

Fei Han, M.D.

Ischemic Preconditioning or Heat Shock Pretreatment Ameliorates Neuronal Apoptosis Following Hypothermic Circulatory Arrest.

 

Bob Garman, D.V.M.

Subventricular Zone Neuroblasts Emigrate Toward Cortical Lesions.

1/20/06

Yi-Chen Lai, M.D.

NMDA Receptors are Expressed in Oligodendrocytes and Activated in Ischaemia.

 

Hülya Bayır, M.D.

A Novel Method to Determine Specificity and Sensitivity of the TUNEL Reaction in the Quantitation of Apoptosis.

 

Hülya Bayır, M.D.

Intravenously Administered Propidium Iodide Labels Necrotic Cells in the Intact Mouse Brain After Injury.

1/13/06

Hong Yan, M.D.

Delayed Hypothermia Preferentially Increases Expression of Brain-Derived Neurotrophic Factor Exon III in Rat Hippocampus after Asphyxial Cardiac Arrest.

 

Anthony Kline, Ph.D.

Electrical Stimulation of the Vagus Nerve Enhances Cognitive and Motor Recovery following Moderate Fluid Percussion Injury in the Rat.

 

Xiangbei Chen, M.D.

The protective effect of nebivovol on ischemia/reperfusion injury in rabbit spinal cord.

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