Program Details
Training Grant Activities

Awards

Ethics in Research Review Session (pdf)

Current Trainees

Neurointensive Care and Resuscitation Research Journal Club

Trainee Bibliography (pdf)

Safar Center Monthly Lecture Series

RESEARCH AWARDS WON BY FELLOWS IN THE INITIAL 4 YRS OF OUR T32

Date

Award

Name

2000

Junior Investigator of the year, Women in Neurotrauma Award,
National Neurotrauma Society

Dr. Statler

2000

Murray Goldstein Award, National Neurotrauma Society

Dr. Satchell

2001

Annual Scientific Award, 30th Congress of SCCM

Dr. Satchell

2003

Educational Scholarship, 32nd Congress of SCCM

Dr. Shore

2003

Educational Scholarship (1), 32nd Congress of SCCM

Dr. Lai

2003

Educational Scholarship (2), 32nd Congress of SCCM

Dr. Lai

2003

Educational Scholarship, 32nd Congress of SCCM

Dr. Nguyen

2003

Abstract Award, NCMRR Training Workshop

Dr. Chadha

2003

Neuroscience Award, 4th WFPICCS Congress

Dr. Shore

2005

Top Paper at Penn/Delaware Heart Association Fellows Day

Dr. Fink

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CURRENT TRAINEES | VIEW FORMER TRAINEES

The Safar Center welcomes two new fellows into our Training in Pediatric Neurointensive Care and Resuscitation Research T32 program.  They join Drs. Erik Su and Alicia Au who are in their second year of training.  This T32 is in its 11th year of funding and was just competitively renewed.  We thank NICHD for supporting this vital program for our center. 

Steven Shein, MD
completed his pediatric residency training at Rainbow Babies and Children’s Hospital in Cleveland, Ohio and is in his third year of PICU fellowship training at Children’s Hospital of Pittsburgh.  He has been studying the effect of hemorrhagic shock on the cytokine and chemokine response to experimental traumatic brain injury using a new murine model.   As a T32 fellow he hopes to carry out both bench and bedside studies.  In the laboratory, related to his initial work, he plans to study the impact of fever on secondary brain injury after experimental traumatic brain injury—mapping the time window for detrimental effects.  In the PICU he plans to carry out a single center exploratory trial of mild hypothermia for seizure control of refractory status epilepticus in children.

Katie Russell, PhD
comes to our T32 as the first postdoctoral fellow from the Department of Physical Medicine and Rehabilitation.  Dr. Russell has a PhD in Neuroscience from the University of Pittsburgh.  She has experience as a postdoctoral fellow studying language deficits after traumatic brain injury including work on white matter injury, working memory, and neuroimaging.  She plans to expand her work into the pediatric traumatic brain injury domain, studying cognitive development and its relationship to rehabilitation of deficits while on the T32.  Her work will be carried out under the joint mentorship of Drs. Amy Wagner and Joseph Ricker.

Dr. Erik Su
Erik Su joined our fellowship program in July 2008 and completed his residency training at the Children's Hospital of Pittsburgh as well.  He has been working with Dr. Hülya Bayır on the utility of alpha synuclein as a marker of neurological injury after traumatic brain injury and the effect of therapeutic hypothermia on its levels, as well correlation of myelin basic protein in the CSF with white matter injury in the pediatric TBI population.  He will continue working with Dr. Bayır this year on neuroimaging findings related to antioxidant therapy after neurological injury.

Dr. Alicia Au
Dr. Au completed her pediatric residency training at Children’s National Medical Center in 2007 and her pediatric critical care medicine fellowship at Children’s Hospital of Pittsburgh in 2010.  Now on the T-32 she is working with Dr. Robert Clark studying autophagy in the brain after pediatric asphyxial cardiac arrest.  In January 2010, she received the Neurology Specialty Award from the Society of Critical Care Medicine.



2012 Neurointensive Care and Resuscitation Research Journal Club

Date

Presenters

Title

3/16/12

Drabek, Dezfulian
  1. Comparison of the Durations of Mild Therapeutic Hypothermia on Outcome After Cardiopulmonary Resuscitation in the Rat.
  2. The difference in myocardial injuries and mitochondrial damages between asphyxial and ventricular fibrillation cardiac arrests.

3/2/12

Ferguson, Fink
  1. Severe traumatic brain injury in children elevates glial fibrillary acidic protein in cerebrospinal fluid and serum.
  2. Serum Levels of Neuron-Specific UCHL1 Predict Brain Injury in a Canine Model of Hypothermic Circulatory Arrest.

2/24/12

Russell, Au
  1. Intellectual Ability 10 Years after Traumatic Brain Injury in Infancy and Childhood: What Predicts Outcome?
  2. Frequency and Timing of Nonconvulsive Status Epilepticus in Comatose Post-Cardiac Arrest Subjects Treated with Hypothermia.

2/10/12

Simon, Shein
  1. Insufficient Activation of Autophagy Allows Cellular Damage to Accumulate in Critically ill Patients.
  2. Sodium nitroprusside-enhanced cardiopulmonary resuscitation improves resuscitation rates after prolonged untreated cardiac arrest in two porcine models.

1/27/12

Simon, Shein
  1. Comparison Between Cerebral Tissue Oxygen Tension and Energy Metabolism in Experimental Subdural Hematoma.
  2. Outcome prediction by motor and papillary responses in children treated with therapeutic hypothermia after cardiac arrest.

1/20/12

Dezfulian, Ferguson
  1. Requirement of argininosuccinate lyase for systemic nitric oxide production.
  2. Intracranial Pressure Changes following Traumatic Brain Injury in Rats: Lack of Significant Change in the Absense of Mass Lesions or Hypoxia.

1/13/12

Mtaweh, Tehranian
  1. Early Enteral Nutrition and Clinical Outcomes of Severe Traumatic Brain Injury Patients in Acute Stage: A Multi-Center Cohort Study.
  2. Minocyline Restores sAPPx Levels and Reduces the Late Histopathological Consequences of Traumatic Brain Injury in Mice.

1/6/12

Russell, Su
  1. What comes first? The dynamics of cerebral oxygenation and blood flow in response to changes in arterial pressure and intracranial pressure after head injury.
  2. Early Microstructural and Metabolic Changes following Controlled Cortical Impact Injury in Rat: A Magnetic Resonance Imaging and Spectroscopy.

2011 Neurointensive Care and Resuscitation Research Journal Club

Date

Presenters

Title

12/16/11

Carter, Tehranian
  1. Stress and traumatic brain injury: a behavioral, proteomics, and histological study.
  2. Post-Stroke Hypothermia Provides Neuroprotection through Inhibition of AMP-Activated Protein Kinase.

12/09/11

Donnelly, Jackson
  1. High Intracranial Pressure Effects on Cerebral Cortical Microvascular Flow in Rats.
  2. Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice.

12/02/11

Huie, Shein
  1. Prognostic Value of Magnetic Resonance Imaging in Moderate and Severe Head Injury: A Prospective Study of Early MRI Findings and One-Year Outcome.
  2. Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation.

11/18/11

Anderson, Brayer
  1. Intracanal Pressure in Compressive Spinal Cord Injury: Reduction with Hypothermia.
  2. Severity Profile of Penetrating Ballistic-Like Brain Injury on Neurofunctional Outcome, Blood-Brain Barrier Permeability, and Brain Edema Formation.

11/11/11

Ferguson, Shein
  1. Critical Thresholds for Cerebrovascular Reactivity After Traumatic Brain Injury.
  2. Comparison of Effects of Equiosmolar Doses of Mannitol and Hypertonic Saline on Cerebral Blood Flow and Metabolism in Traumatic Brain Injury.

11/04/11

Willyerd, Harun
  1. Free-Radical Scavenger Edaravone Treatment Confers Neuroprotection Against Traumatic Brain Injury in Rats.
  2. The Salutary Effects of DHA Dietary Supplementation on Cognition, Neuroplasticity, and Membrane Homeostasis after Brain Trauma.

10/28/11

Au, Su
  1. Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats.
  2. Time-Dependent Changes in Serum Biomarker Levels after Blast Traumatic Brain Injury.

10/21/11

Newell, Casey
  1. Repetitive Closed-Skull Traumatic Brain Injury in Mice Causes Persistent Multifocal Axonal Injury and Microglial Reactivity.
  2. Can a Cold (4°C) IV Fluid Bolus to Induce Therapeutic Hypothermia Really Deliver 4°C to Children?

10/14/11

Russell, Manole
  1. Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity.
  2. Intravital Oxygen Radical Imaging in Normal and Ischemic Rat Cortex.

10/7/11

Ferguson, Carter
  1. Vasopressor Use and Effect on Blood Pressure After Severe Adult Traumatic Brain Injury.
  2. Zinc supplementation provides behavioral resiliency in a rat model of traumatic brain injury.

9/30/11

Su, Bhasha
  1. Noninvasive assessment of the brain redox status after transient middle cerebral artery occlusion using Overhauser-enhanced magnetic resonance imaging.
  2. Effect of pharmaceutical treatment on vasospasm, delayed cerebral ischemia, and clinical outcome in patients with aneurismal subarachnoid hemorrhage: a systemic review and meta-analysis.

9/23/11

Shein
  1. Reduced brain edema and functional deficits after treatment of diffuse traumatic brain injury by carbamylated erythropoietin derivative.

9/16/11

Willyerd, Brockman
  1. Short-Term Moderate Hypocapnia Augments Detection of Optimal Cerebral Perfusion Pressure.
  2. The Combination of Either Tempol or FK506 with Delayed Hypothermia: Implications for Traumatically Induced Microvascular and Axonal Protection.

9/9/11

Shein, Willyerd
  1. Randomized Controlled Trial Comparing the Effect of 8.4% Sodium Bicarbonate and 5% Sodium Chloride on Raised Intracranial Pressure after Traumatic Brain Injury.
  2. Abnormal Neuroimaging is Associated with Early In-Hospital Seizures in Pediatric Abusive Head Trauma.

9/2/11

Carter, Russell
  1. The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using Fourier analysis of stained tissue sections.
  2. Error-related processing following severe traumatic brain injury: An event-related functional magnetic resonance imaging (fMRI) study.

8/26/11

Tehranian, Brockman
  1. Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice.
  2. Impact of Continuous EEG Monitoring on Clinical Management in Critically Ill Children.

8/19/11

Dezfulian, Watkins
  1. S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury.
  2. Acute systemic erythropoietin therapy to reduce delayed ischemic deficits following aneurismal subarachnoid hemorrhage: a Phase II randomized, double-blind, placebo-controlled trial.

8/12/11

Au, Kochanek
  1. HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration.
  2. Levetiracetam is Associated with improved Cognitive Outcome for Patients with Intracranial Hemorrhage.

8/5/11

Russell, Jackson
  1. Prefrontal compensatory engagement in TBI is due to altered functional engagement of existing networks and not functional reorganization.
  2. Mechanical Heterogeneity of the Rat Hippocampus Measured by Atomic Force Microscope Indentation.

7/29/11

Carter, Su
  1. The Role of the Met66 Brain-Derived Neurotrophic Factor Allele in the Recovery of Executive Functioning after Combat-Related Traumatic Brain Injury.
  2. In vivo imaging of mitochondrial function in methamphetamine-treated rats.

7/22/11

Tehranian, Kochanek
  1. Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy.
  2. Neuropathological Findings in Disabled Survivors of a Head Injury.

7/15/11

Shein, Russell
  1. Surface Cooling after Cardiac Arrest: Effectiveness, Skin Safety, and Adverse Events in Routine Clinical Practice.
  2. Diffusion Tensor Imaging of the Perforant Pathway Zone and Its Relation to Memory Function in Patients with Severe Traumatic Brain Injury.

7/8/11

Au, Donnelly
  1. A prospective, randomized clinical trial to compare the effect of hyperbaric to normobaric hyperoxia on cerebral metabolism, intracranial pressure, and oxygen toxicity in severe traumatic brain injury.
  2. Isolated human and rat cerebral arteries constrict to increases in flow: role of 20-HETE and TP receptors.

7/1/11

Su, Harun
  1. Increase in Blood-Brain Barrier Permeability, Oxidative Stress, and Activated Microglia in a Rat Model of Blast-Induced Traumatic Brain Injury.
  2. Isoflurane-induced Neuroapoptosis in the Neonatal Rhesus Macaque Brain.

6/17/11

Jackson, Anderson
  1. LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes?
  2. Early Post-Traumatic Seizures in Moderate to Severe Pediatric Traumatic Brain Injury: Rates, Risk Factors, and Clinical Features.

6/10/11

Basha, Blaziole
  1. Prostacyclin Infusion May Prevent Secondary Damage in Pericontusional Brain Tissue.
  2. Influence of 100% and 40% oxygen on penumbral blood flow, oxygen level, and T2-weighted MRI in a rat stroke model.

6/3/11

Ferguson, Dezfulian
  1. Medical Management of Compromised Brain Oxygen in Patients with Severe Traumatic Brain Injury.
  2. Variants of the Endothelial Nitric Oxide Gene and Cerebral Blood Flow after Severe Traumatic Brain Injury.

5/27/11

Au, Tehranian
  1. Neuroprotective Effects of Hyperbaric Oxygen Treatment on Traumatic Brain Injury in the Rat.
  2. Cyclosporin A Preserves Mitochondrial Function after Traumatic Brain Injury in the Immature Rat and Piglet.

5/20/11

Harun, Salonia
  1. Reduced neuronal nitric oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression.
  2. Cardiac arrhythmias associated with severe traumatic brain injury and hypothermia therapy.

5/13/11

Fink,

Carter
  1. Abnormal Microstructure of the Atrophic Thalamus in Preterm Survivors with Periventricular Leukomalacia
  2. The serotonin transporter polymorphisms and major depression following traumatic brain injury

5/06/11

Mehta,

Su
  1. Diagnostic Value of the Glasgow Coma Scale for Traumatic Brain Injury in 18,002 Patients with Severe Multiple Injuries
  2. Diffusion Tensor Imaging of Incentive Effects in Prospective Memory after Pediatric Traumatic Brain Injury

4/29/11

Dezfulian,

Shein

  1. Outcomes of chest compression only CPR versus conventional CPR conducted by lay people in patients with out of hospital cardiopulmonary arrest witnessed by bystanders: nationwide population based observational study
  2. Short-Term outcome prediction by electroencephalographic features in children treated with therapeutic hypothermia after cardiac arrest

4/22/11

Cancelled

4/15/11

Zhou,

Tehranian
  1. Erythropoietin improved initial resuscitation and increased survival after cardiac arrest in rats
  2. Neuron specific enolase and S-100B as predictors of outcome after cardiac arrest and induced hypothermia

4/08/11

Smith,

Au
  1. Favorable Outcome in Traumatic Brain Injury Patients With Impaired Cerebral Pressure Autoregulation When Treated at Low Cerebral Perfusion Pressure Levels
  2. Nonconvulsive seizures after traumatic brain injury are associated with hippocampal atrophy

4/01/11

Su,

Zhou
  1. Decompressive Craniectomy in Diffuse Traumatic Brain Injury
  2. Robust Docosahexaenoic Acid-Mediated Neuroprotection in a Rat Model of Transient, Focal Cerebral Ischemia

3/25/11

Shein,

Smith
  1. Analyses of Cerebral Microdialysis in Patients with Traumatic Brain Injury: Relations to Intracranial Pressure, Cerebral Perfusion Pressure and Catheter Placement
  2. Craniotomy: True Sham for Traumatic Brain Injury, or a Sham of a Sham?

3/18/11

Au,

Kline
  1. αII-Spectrin Breakdown Products (SBDPs): Diagnosis and Outcome in Severe Traumatic Brain Injury Patients
  2. Longitudinal Characterization of Motor and Cognitive Deficits in a Model of Penetrating Ballistic-Like Brain Injury

3/11/11

  

Canceled

3/4/11

Ferguson,

Smith
  1. Mortality in Children with Severe Head Trauma: Predictive Factors and Proposal for a New Predictive Scale
  2. Combining Coma Score and Serum Biomarker Levels to Predict Unfavorable Outcome Following Childhood Brain Trauma

2/25/11

  

Canceled

2/18/11

  

Canceled

2/11/11

Brockman,

Au
  1. Minocycline Synergizes with N-Acetylcysteine and Improves Cognition and Memory Following Traumatic Brain Injury in Rats
  2. Very Early Hypothermia Induction in Patients with Severe Brain Injury (The National Acute Brain Injury Study: Hypothermia II): A Randomized Trial

2/4/11

Newell,

Mehta
  1. Systemic LPS Causes Chronic Neuroinflammation and Progressive Neurodegeneration
  2. Intrathecal Pressure Monitoring and Cerebrospinal Fluid Drainage in Acute Spinal Cord Injury: A Prospective Randomized Trial

1/28/11

Tehranian-DePasquale,

Donnelly
  1. In Vivo Imaging of Autophagy in a Mouse Stroke Model
  2. Inhibition of TRPC6 Degradation Suppresses Ischemic Brain Damage in Rats

1/21/11

Salonia,

Zhou
  1. Second-Impact Syndrome and a Small Subdural Hematoma: An Uncommon Catastophic Result of Repetitive Head Injury with a Characteristic Imaging Appearance
  2. Cytotoxic Edema: Monitoring Its Magnitude and Contribution to Brain Swelling

1/14/11

  

Canceled

1/7/11

Shein,

Manole
  1. Microglia: Proliferation and Activation Driven by the P2X7 Receptor
  2. Metabolic Crisis without Brain Ischemia is Common after Traumatic Brain Injury: A Combined Microdialysis and Positron Emission Tomography Study

2010 | 2009 | 2008 | 2007 | 2006 | 2005

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Safar Center Monthly Lecture Series

Date

Speaker

Title

3/13/12

Cameron Dezfulian, MD

Rodent cardiac arrest models, nitrite therapy and mitochondrial function

2/14/12

Dandan Sun, MD, PhD

Ion Transporters in Hypoxic and Ischemic Brain Injury

1/31/12

Alicia Au, MD

From Basic Science to Biomarkers: A T32’s Perspective on Brain Injury Research

12/8/11

Audrey Lafrenaye, PhD

Special Lecture: Increased Intracranial Pressure Following Diffuse Traumatic Brain Injury: Implications for Axonal Injury and Neuronal Somatic Perturbation

12/6/11

Jon Verrier, PhD

The 2’, 3’, -cAMP-Adenosine Pathway as a Potential Endogenous Neuroprotective Mechanism Post-Injury

11/9/11

Barclay Morrison III, PhD

Special Lecture: Traumatic Brain Injury Tolerances: In Vitro Insights

11/8/11

Mike Bell, MD

Pediatric Neurotrauma Center: Neurocritical Care Service & TBI Program

10/11/11

Clifton Callaway, MD

Cardiac Arrest Program at UPMC - Presbyterian

9/14/11

Mark Gladwin, MD

Role of the Anion Nitrate in Physiological Hypoxic Signaling and Therapeutics

8/30/11

Kevin Hitchens, PhD

Imaging the Immune Response with Cellular MRI

7/26/11

Larry Jenkins, PhD

PKA Signaling and CCI

5/24/11

Ava Puccio, RN, PhD

Current and Pending Adult TBI Clinical Trials

4/12/11

Rachel P. Berger, MD, MPH

Serum and CSF sample collection, storage and documentation: What every fellow needs to know

3/30/11

Amy Wagner, MD

What is so ‘Spatial’ about MWM testing after Experimental TBI?

2/8/11

Travis Jackson, PhD

 PHLPP1 Mediated Inhibition of Neuronal Survival Signaling: A New Therapeutic Target in Brain Injury

1/11/11

Samuel Shin, PhD

Dopaminergic Deficits after TBI and Nicotine Treatment

12/13/10

Hülya Bayır, MD

Structural adaptation of mitochondrial superoxide dismutase to redox stress: Implications for therapeutic targeting.

11/23/10

Erika Fink, MD

Biomarker craziness after pediatric cardiac arrest

10/12/10

Andreas Janata, MD

VF,CPR,CPB-Opportunities and Challenges of a Novel Rat Cardiac Arrest Model

9/14/10

Dr. Kline’s Group

Ongoing evaluation of neurogenesis, 5-HT1A vs. 5-HT7 receptors, and antipsychotics after CCI injury

8/10/10

Jocelyn Zhou, PhD

Hypothermia effect on CYP isoform specific drug metabolism after cardiac arrest

7/13/10

Mioara Manole, MD

Brain oxygenation after pediatric asphyxial  cardiac arrest

6/8/10

Edwin Jackson, MD

2,3,-Cyclic AMP: Friend or Foe?

5/11/10

Dr. Graham’s Group

Role of cyclopentenone prostaglandins in modifying UCHL1 activity

4/13/10

Dr. Wagner’s Group

Hormones in TBI

3/9/10        

Dr. Jenkin’s Group

Memory - what's synaptic plasticity got to do with it?

2/17/10       

James Bales, PhD

The DARPP-32 Signaling Cascade: How to Make TBI Even More Complex

12/8/09

Hülya Bayır, MD

Lipid-Dependent Cross-Linking Of Synuclein With Cytochrome c: Protection Against Neuronal Apoptosis Versus Delayed Oxidative Stress

11/10/09

Patrick Kochanek, MD

Blast TBI- Pathobiology and Resuscitation

10/14/09

Erika Fink, MD

Stone Cold Brain Biomarkers after Pediatric Cardiac Arrest

9/15/09

Anthony Kline, PhD

Rehabilitation-relevant therapies for adult and pediatric TBI

7/28/09

Mioara Manole, MD

Post-Cardiac Arrest Syndrome: Cerebral Monitoring

5/12/09

Dr. Graham’s Group

The Role of Cyclopentenone Prostaglandins in Ischemia and Trauma: A UPPer or a Downer?

4/21/09

Dr. Wagner’s Group

Update on DA Neurotransmission in CCI

3/17/09

Dr. Dixon’s Group

Differential Localization of Hic-5 and Paxillin in the Brain of Alzheimer’s Disease Subjects

2/17/09

Dr. Bayır’s Group

Peroxidase activity of hemoglobin/haptoglobin complexes: Covalent aggregation and oxidative stress in plasma and macrophages

1/13/09

Xianren Wu, MD

Hemoglobin-based products in resuscitation of TBI+HS

12/11/08

Dr. Clark’s Group

Teaching Old Drugs New Tricks

10/9/08

Dr. Jenkin’s Group

Epigenetic Signals After TBI

9/11/08

Robert Hickey, MD

Cyclooxygenase 2(COX2), ER Stress and Brain Ischemia: is Protein Disulfide Isomerase Relevant?

8/20/08

Dr. Fink’s Group

Chillin’ at Children’s

7/10/08

Dr. Kline’s Group

Combinational therapies after experimental traumatic brain injury

6/12/08

Dr. Graham’s Group

Beyond Vioxx-Development of New Neuroprotective Therapies for Stroke and Trauma that Target Cyclooxygenase 2 Activity

5/8/08

Dr. DeKosky’s Group

The effect of statin intervention on brain inflammation following TBI

4/17/08

Dr. Bayır’s Group

Oxidative Lipidomics in TBI

3/13/08

Dr. Wagner’s Group

An Update on MWM Data Analysis and on Dilantin Therapy in Experimental TBI

1/10/08

Dr. Dixon’s Group

The World According to DARPP-32:  Effects of TBI

1/24/07

Karen Walson, MD

Peroxidase Activity of Hemoproteins Released into Biofluids as Source of Oxidative Stress:  Case in Sepsis

1/29/07

Sten Rubertsson, MD, PhD, EDIC, FCCM

Nasal Selective Brain Cooling

2/7/07

David F. Meaney, PhD

Targeting NMDA Receptors to Control Neuronal Fate after Traumatic Brain Injury

3/14/07

Yvette P. Conley, M.D.

Mitochondrial Genetics and TBI

4/18/07

Mioara Manole, M.D.

Fuel for the Brain

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