Program Details
Training Grant Activites

Awards

Ethics in Research Review Session (pdf)

Current Trainees

Neurointensive Care and Resuscitation Research Journal Club

Trainee Bibliography (pdf)

2007 Safar Center Monthly Lecture Series

Our training program is currently in its 5th year of funding. The trainees who were funded by this T32 are shown below. Eight candidates (Drs. Margaret Satchell, Kimberly Statler, Trung Nguyen, Yong Han, Mary Hartman, Paul Shore, Mandeep Chadha and Melinda Fiedor) have completed our program, 2 are in their second year of training (Drs. Ericka Fink & Yi-Chen Lai). The research accomplishments include two funded K12 awards (Statler, Nguyen) and one submitted (Fink) along with a K-23 (Shore) and RO-8 (Lai) currently submitted, and an American Heart Association, Texas Affiliate to Dr. Nguyen. Dr. Hartman, is completing some additional clinical training. The publications of all of our trainees while working on the T32 are provided below including a bibliography and awards, respectively. As of the time of submission of this renewal, our trainees, while funded by this T32, have published or in press 23 peer-reviewed manuscripts (18 as first author), and 62 abstracts (43 as first author). They have also been authors or co-authors of 2 reviews and 11 chapters or editorials. Numerous manuscripts are still in preparation or being submitted for publication. Each of our trainees has given multiple presentations at the major national or international meetings in the related fields. Seven of the 10 fellows funded by the T32 have received awards at major scientific meetings—2 have received multiple awards. Finally, our fellows have published in excellent journals. The average impact factor for cited papers was 3.86.

RESEARCH AWARDS WON BY FELLOWS IN THE INITIAL 4 YRS OF OUR T32

Date

Award

Name

2000

Junior Investigator of the year, Women in Neurotrauma Award, National Neurotrauma Society

Dr. Statler

2000

Murray Goldstein Award, National Neurotrauma Society

Dr. Satchell

2001

Annual Scientific Award, 30th Congress of SCCM

Dr. Satchell

2003

Educational Scholarship, 32nd Congress of SCCM

Dr. Shore

2003

Educational Scholarship (1), 32nd Congress of SCCM

Dr. Lai

2003

Educational Scholarship (2), 32nd Congress of SCCM

Dr. Lai

2003

Educational Scholarship, 32nd Congress of SCCM

Dr. Nguyen

2003

Abstract Award, NCMRR Training Workshop

Dr. Chadha

2003

Neuroscience Award, 4th WFPICCS Congress

Dr. Shore

2005

Top Paper at Penn/Delaware Heart Association Fellows Day

Dr. Fink

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CURRENT TRAINEES | VIEW FORMER TRAINEES

Bales

James Bales
is an MD/PhD student currently attending the University of Pittsburgh as a member of the Medical Scientist Training Program. He did his undergraduate education at Washington State University in Pullman, WA. In 2007, he finished the first two years of his medical degree and has transitioned into the graduate years of his program. James is doing his graduate training in the lab of Dr. C. Edward Dixon examining the molecular changes in striatal neurotransmitter systems, particularly dopamine, following traumatic brain injury and their relation to functional deficits.


Exo

Dr. Jennifer Exo
joined the Pediatric Critical Care Medicine fellowship program in July 2006, and recently selected the Safar Center for Resuscitation Research to carry out her research. Jennifer did her residency at Advocate Hope Children’s Hospital. Dr. Exo has just begun experiments—and is testing novel resuscitation strategies in a mouse model of combined traumatic brain injury and hemorrhagic shock. Currently, she is comparing polynitroxylated albumin and hypertonic saline to conventional resuscitation fluids such as hetastarch and lactated Ringers solution and is assessing both acute and long-term outcome parameters, along with markers of oxidative stress in this model, which is being mentored by Drs. Kochanek, Bayır, and Dixon, is supported by a program project grant from the United States Army.


Salonia

Dr. Rosanne Salonia
is currently a fellow in the Pediatric Critical Care Medicine program at Children’s Hospital of Pittsburgh. She did her residency training at SUNY Upstate Medical University Hospital. Dr. Salonia is interested in the area of inflicted childhood neurotrauma and the development of novel diagnostic tools for this important condition. She has recently begun research in this area working under the mentorship of Dr. Rachel Berger.



Smith

Dr. Craig Smith
joined our fellowship program in July 2005. He did his pediatric residency training at Connecticut Children’s Medical Center and is currently a second year fellow in Pediatric Critical Care Medicine. Dr. Smith is working under the mentorship of Dr. Robert Clark studying the role of poly-ADP ribose polymerase (PARP) in experimental traumatic brain injury. In February 2007, Dr. Smith received the scientific award from the Society of Critical Care Medicine for his work on the effect of gender on sub-cellular localization of PARP-activation after experimental traumatic brain injury in developing rats. Dr. Smith will join our T32 training program in Pediatric Neurointensive Care and Research beginning in July 2007.


Neurointensive Care and Resuscitation Research Journal Club

Date

Presenters

Title

9/4/09

Smith, Watkins

1. Inpatient Hyperglycemia Following Aneurysmal Subarachnoid Hemorrhage: Relation to Cerebral Metabolism and Outcome.

2. Relationship Between Hemoglobin Concentrations and Outcomes Across Subgroups of Patients with Aneurysmal Subarachnoid Hemorrhage.

8/21/09

Au, Magnet

1. RNA Interference-Mediated Downregulation of Beclin1 Attenuates Cerebral Ischemic Injury in Rats.

2. Ischemic Postconditioning Protects against Global Cerebral Ischemia/Reperfusion-Induced Injury in Rats.

8/14/09

 

Student Research Day

8/7/09

Su, Baltagi

1. Novel Diffusion Tensor Imaging Methodology to Detect and Quantify Injured Regions and Affected Brain Pathways in Traumatic Brain Injury.

2. Brain Tissue Oxygen and Outcome after Severe Traumatic Brain Injury: A Systematic Review.

7/31/09

Bales, Donnelly

1. Dopamine Depletion Induces Distinct Compensatory Gene Expression Changes in DARPP-32 Signal Transduction Cascades of Striatonigral and Striatopallidal Neurons.

2. Excision Repair Cross-Complementing 1 Expression Protects against Ischemic Injury Following Middle Cerebral Artery Occlusion in the Rat Brain

7/24/09

Shin, Exo

1. Modulation of the cAMP Signaling Pathway after Traumatic Brain Injury.

2. Adenosine A2A Receptor Mediates Microglial Process Retraction

7/17/09

Janata, Shoykhet

1. Continuous Electroencephalography in the Medical Intensive Care Unit.

2. Therapeutic Administration of Plasminogen Activator Inhibitor-1 Prevents Hypoxic-Ischemic Brain Injury in Newborns

7/10/09

Exo, Au, Mueller

1. An Early Bolus of Hypertonic Saline Hydroxyethyl Starch Improves Long-Term Outcome after Global Cerebral Ischemia.

2. Equimolar Doses of Mannitol and Hypertonic Saline in the Treatment of Increased Intracranial Pressure.

3. Opposed Effects of Hypertonic Saline on Contusions and Noncontused Brain Tissue in Patients with Severe Traumatic Brain Injury.

7/3/09

Smith, Bayır

1. Glibenclamide Reduces Inflammation, Vasogenic Edema, and Caspase-3 Activation after Subarachnoid Hemorrhage.

2. NADPH Oxidase is the Primary Source of Superoxide Induced by NMDA Receptor Activation.

6/26/09

Buckalew, Caltagarone

1. Proton MR Spectroscopic Imaging Depicts Diffuse Axonal Injury in Children with Traumatic Brain Injury.

2. Disruption of the Ubiquitin Proteasome System following Axonal Stretch Injury Accelerates Progression to Secondary Axotomy.

6/19/09

Au, Su

1. Xenon and Hypothermia Combine Additively, Offering Long-Term Functional and Histopathologic Neuroprotection after Neonatal Hypoxia/Ischemia.

2. αll-Spectrin Breakdown Product Cerebrospinal Fluid Exposure Metrics Suggest Differences in Cellular Injury Mechanisms after Severe Traumatic Brain Injury.

6/12/09

Canceled.

 

6/5/09

Bales, Zou

1. Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum.

2. Recovery of Learning and Memory is Associated with Chromatin Remodelling.

5/29/09

Tehranian, Fink

1. The Chemokine Receptor CXCR2 is Differentially Regulated on Glial Cells In Vivo but is not Required for Successful Remyelination after Cuprizone-Induced Demyelination.

2. Pediatric Cardiopulmonary Resuscitation: Advances in Science, Techniques, and Outcomes.

5/22/09

Exo, Kline

1. Status Epilepticus Induces a Particular Microglial Activation State Characterized by Enhanced Purinergic Signaling.

2. Strain Differences in Response to Traumatic Brain Injury in Long-Evans Compared to Sprague-Dawley Rats.

5/15/09

Smith, Mueller

1. ABC Transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ABCG2) Expression in the Developing Human CNS.

2. Serial Changes in the White Matter Diffusion Tensor Imaging Metrics in Moderate Traumatic Brain Injury and Correlation with Neuro-Cognitive Function.

5/8/09

Canceled


5/1/09

Sarnaik, Caltagarone

1. Inducible Nitric Oxide Synthase Promoter Polymorphism Affords Protection against Cognitive Dysfunction after Carotid Endarterectomy.

2. Intrinsic Neurons of Fastigial Nucleus Mediate Neurogenic Neuroprotection against Excitotoxic and Ischemic Neuronal Injury in Rat.

4/24/09

Canceled

 

4/17/09

Manole, Su

1. Hypothermia Therapy after Pediatric Cardiac Arrest.

2. Age-Dependent Synuclein Pathology Following Traumatic Brain Injury in Mice.

4/3/09

Shoykhet, Donnelly

1. Effect of 35°C Hypothermia on Intracranial Pressure and Clinical Outcome in Patients with Severe Traumatic Brain Injury.

2. Effect of 20-HETE Inhibition on Infarct Volume and Cerebral Blood Flow after Transient Middle Cerebral Artery Occlusion.

3/27/09

Exo, Zou

1. ATP Mediates Rapid Microglial Response to Local Brain Injury in vivo.

2. NMDA Receptors are Expressed in Developing Oligodendrocyte Processes and Mediate Injury.

3/20/09

Smith, Bales, Au

1. Long-Lasting Benefits after Treatment of Traumatic Brain Injury (TBI) in Rats with Combination Therapy of Marrow Stromal Cells (MSCs) and Simvastatin.

2. Na+, K+-ATPase Phosphorylation in the Choroid Plexus: Synergistic Regulation by Serotonin/Protein Kinase C and Isoproterenol/cAMP-PK/PP-1 Pathways.

3. Protective Role of Autophagy in Neonatal Hypoxia-Ischemia Induced Brain Injury.

3/13/09

Smith, Zhou, Mueller, Shoykhet

1. Hypothermia for Refractory Status Epilepticus.

2. Effects of Mild Hypothermia and Rewarming on Renal Function after Coronary Artery Bypass Grafting.

3. Cerebrovascular Reactivity during Hypothermia and Rewarming.

4. Effect of 35°C Hypothermia on Intracranial Pressure and Clinical Outcome in Patients with Severe Traumatic Brain Injury.

3/6/09

Garman, Sarnaik, Shellington

1. Basophilia, Acidophilia and Argyrophilia of “Dark” (Compacted) Neurons during their Formation, Recovery or Death in an Otherwise Undamaged Environment.

2. The Effects of a Ketogenic Diet on Behavioral Outcome after Controlled Cortical Impact Injury in the Juvenile and Adult Rat.

3. Live Imaging of Toll-Like Receptor 2 Response in Cerebral Ischemia Reveals a Role of Olfactory Bulb Microglia as Modulators of Inflammation.

2/27/09

Shellington, Smith

1. Neurotoxicity of Hemoglobin in Cortical Cell Culture.

2. Glutamate Up-Regulates P-Glycoprotein Expression in Rat Brain Microvessel Endothelial Cells by an NMDA Receptor-Mediated Mechanism.

2/20/09

Canceled

 

2/13/09

Tehranian, Shin

1. Hyperoxia Causes Maturation-Dependent Cell Death in the Developing White Matter.

2. Neuroinflammation and Oxidation/Nitration of α-Synuclein Linked to Dopaminergic Neurodegeneration.

1/30/09

Smith, Mueller

1. Acute, Regional Inflammatory Response after Traumatic Brain Injury: Implications for Cellular Therapy.

2. Proinflammatory Cytokine Production by Cultured Neonatal Rat Microglia after Exposure to Blood Products.

1/23/09

Exo, Fink

1. Intracerebroventricular Injection of Microglia Protects against Focal Brain Ischemia.

2. Hypoglycemic Neuronal Death is Triggered by Glucose Reperfusion and Activation of Neuronal NADPH Oxidase.

1/16/09

Empey, Bales

1. Gene Variants Associated with Ischemic Stroke. The Cardiovascular Health Study.

2. Opposing Patterns of Signaling Activation in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons in Response to Cocaine and Haloperidol

1/9/09

Alexander, Caltagarone

1. Alpha-Stat Versus pH-Stat Guided Ventilation in Patients with Large Ischemic Stroke Treated by Hypothermia.

2. The Chemokine Stromal Cell-Derived Factor-1 Regulates GABAergic Inputs to Neural Progenitors in the Postnatal Dentate Gyrus.

1/2/09

Cancelled

12/26/08

Cancelled

 

12/19/08

Smith, Mueller

1. Simvastatin and Atorvastatin Improve Behavioral Outcome, Reduce Hippocampal Degeneration, and Improve Cerebral Blood Flow after Experimental Traumatic Brain Injury.

2. Early and Sustained Alterations in Cerebral Metabolism after Traumatic Brain Injury in Immature Rats.

12/12/08

Sarnaik, Shellington

S100B Protein is Released from Rat Neonatal Neurons, Astrocytes, and Microglia by In Vitro Trauma and Anti-S100 Increases Trauma-Induced Delayed Neuronal Injury and Negates the Protective Effect of Exogenous S100B on Neurons.
2. Another Barrier to Regeneration in the CNS: Activated Macrophages Induced Extensive Retraction of Dystrophic Axons through Direct Physical Interactions.

12/5/08

Zou, Garman

1. Histone Deacetylase Inhibitors Exhibit Anti-Inflammatory and Neuroprotective Effects in a Rat Permanent Ischemic Model of Stroke: Multiple Mechanisms of Action.
2. Pharmacologic Analysis of the Mechanism of Dark Neuron Production in Cerebral Cortex.

11/21/08

Manole, Wu

1. Perivascular Nitric Oxide and Superoxide in Neonatal Cerebral Hypoxia-Ischemia.
2. Pre-Conditioning Induced by Carbon Monoxide Provides Neuronal Protection against Apoptosis.

11/7/08

Shin, Shellington

1. Soluble Amyloid Precursor Protein α Reduces Neuronal Injury and Improves Functional Outcome Following Diffuse Traumatic Brain Injury in Rats.
2. Macrophage-Independent T Cell Infiltration to the Site of Injury-Induced Brain Inflammation.

2008 | 2007 | 2006 | 2005

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2007 Safar Center Monthly Lecture Series

Date

Speaker

Title

1/24/07

Karen Walson, MD

Peroxidase Activity of Hemoproteins Released into Biofluids as Source of Oxidative Stress:  Case in Sepsis

1/29/07

Sten Rubertsson, MD, PhD, EDIC, FCCM

Nasal Selective Brain Cooling

2/7/07

David F. Meaney, PhD

Targeting NMDA Receptors to Control Neuronal Fate after Traumatic Brain Injury

3/14/07

Yvette P. Conley, M.D.

Mitochondrial Genetics and TBI

4/18/07

Mioara Manole, M.D.

Fuel for the Brain

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