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Ericka Fink, MD
Dr. Fink is in her second year on
the T32. She is working under the mentorship of Dr. Robert Clark and
is studying experimental asphyxial CA in a rat model. Her ATs are Drs.
Dixon and Kochanek. She has been highly productive in her first year
having published a full manuscript on this new model relevant to our
field in Pediatric Critical Care Medicine, and more recently, a report
on the beneficial effect of mild hypothermia in this model—in the
journal Developmental Neuroscience. Her current work is assessing the
effects of the brain penetrating antioxidant GCEE in her model, for which
she received an award for the top paper presented at the 2005 Fellows
Day meeting of the Pennsylvania-Delaware Heart Association. She is also
in the Masters of Clinical Research program at the University of Pittsburgh
and plans to obtain a Master’s degree in her second year of training.
Yi-Chen Lai, MD
Dr. Lai is in his second year on
the T32 and is similarly working under the mentorship of Dr. Clark. His
committee includes Drs. Jenkins and Kochanek as ATs. Dr. Lai is working
on the stress response in brain injury and is focused on HSP70. He has
already published a clinical report on HSP 70 expression in infants and
children with TBI in the Journal of Neurotrauma and a paper in the Journal
of Neurochemistry on the use of TAT-HSP delivery in an in vitro brain
injury model in neuronal culture. Yi-Chen is also a co-author on 4 additional
manuscripts including a paper in the Journal of Biological Chemistry.
He is expanding his work to isolated mitochondria in his most recent
studies where he is evaluating the effect of PARP activation in the stress
response to peroxynitrate-induced injury. His most recent work was presented
at the 2004 meeting of the Society for Neuroscience and the 2005 SCCM
Congress. He has received 2 scientific awards from the SCCM. He will
continue is focus in basic neuroscience in cell stress during the second
year on the T32.
Kimberly Statler, MD
Dr. Statler also completed
her training on the T32 on June 30th, 2002. She worked with Dr. Kochanek
studying the effect of sedation and anesthesia in experimental TBI. Her
ATs were Drs. Dixon, Marion, Jenkins, and Wisniewski. During her training,
she acquired a grant from the Laerdal Foundation and received the Woman
in Neurotrauma award from the National Neurotrauma Society. She published
4 manuscripts as a first author in the area of anesthetic effects in
experimental TBI and has a fifth paper in press in the Journal of Neurotrauma
and a sixth submitted to Brain Research. She carried out the most comprehensive
evaluation to date of anesthetics in experimental TBI. She presented
abstracts at numerous conferences. Dr. Statler’s fourth manuscript
was featured on the cover of the Feb. 6th, 2004 issue of Brain Research.
The article was published in December 2003 in that same journal. Her
collected work on the T32 has already been cited 66 times in the literature.
She is on the faculty of the Department of Pediatrics (CCM), University
of Utah. She has gone on to obtain a Masters in Clinical Research and
is funded by a K12 at the University of Utah in the area of experimental
epilepsy in developmental neurotrauma.
Margaret Satchell, MD
Dr. Satchell completed her
training on the T32 on June 30th, 2003. She worked with Dr. Robert Clark
(PT) in the area of poly ADP ribose polymerase (PARP) activation in TBI.
Her ATs were Drs. Dixon, Jenkins, and Kochanek. During her training,
Margaret gave presentations of her research at the Society for Neuroscience,
National Neurotrauma Society [2], and SCCM [2]) and garnered several
awards including the prestigious Murray Goldstein Award at the National
Neurotrauma Society meeting and a Scientific Award from the SCCM. Dr.
Satchell had a comprehensive first-author manuscript published in the
Journal of Neurochemistry entitled “A dual role of poly-ADP-ribosylation
in spatial memory acquisition after TBI in mice involving NAD+ depletion
and ribosylation of 14-3-3γ.” She has a second manuscript
on cytochrome-c release in CSF after TBI in infants and children that
is in press in Journal of Cerebral Blood Flow and Metabolism. She has
another manuscript on PARP activation in human cerebral contusions in
preparation. She is currently on the faculty in the Dept. of Pediatrics
(CCM division) in the Mount Sinai School of Medicine in New York.
Yong Han, MD
Dr. Han completed training on the T32
in June of 2003. Dr. Han worked in the area of shock (both clinical
and basic) and studied mitochondrial failure and markers of injury
with Dr. Reynolds as his laboratory mentor (AT) and Dr. Carcillo
as his clinical mentor (PT). Dr. Clark was also an AT for Dr. Han.
Dr. Han presented abstracts at numerous scientific meetings. He authored
7 papers while on the T32 including an important recent report in
the journal Pediatrics on shock in the pre-hospital phase in critically
ill infants and children, 2 first-author papers on procalcitonin
in pediatric shock and pediatric TBI, both published in Pediatric
Critical Care Medicine, and 2 manuscripts as a co-author on mitochondrial
failure, one in the Journal of Biological Chemistry and one in Experimental
Neurology. His collected work on the T32 has already been cited 55
times in the literature. He recently joined the CCM faculty in the
Department of Pediatrics at the University of Michigan, is preparing
a K0-8 application and is pursuing an academic career.
Trung Nguyen, MD
Dr. Nguyen completed training on the T32 in June of
2003. He worked with Dr. Carcillo (PT) with AT input from Drs. Wisniewski,
Clark, and the late Dr. Safar on the role of microvascular thrombosis
in the development of MOF after shock and resuscitation. Dr. Nguyen carried
out detailed studies of the coagulation cascade in infants and children
with shock and MOF. He evaluated plasma exchange therapy in a positive
RCT. He presented 7 abstracts and won an Educational Scholarship from
SCCM for work on “Von Willebrand factor cleaving protease
in children with MOF.” He was a highly recruited fellow and chose
a faculty position at the Baylor College of Medicine–working on
the PICU faculty and continuing his research with Dr. Jose Lopez, an
expert in the molecular biology of coagulation. Dr. Nguyen carried out
an RCT on the use of plasma exchange in the treatment of thrombocytopenia-associated
multiple organ failure—work that is in preparation for submission
to the journal Blood. He also published, as first author, a review article
on coagulation in microvascular failure in MOF in Pediatric Critical
Care Medicine. He was just funded by a K12 in the Department of Pediatrics
at Baylor, and by a grant for the American Heart Association, Texas Affiliate
working in the area of the molecular biology of coagulation disturbances
in shock. I believe that he will have a longstanding career as a clinician-scientist.
Mary
Hartman, MD
Dr. Hartman completed her training on the T32 in
June of 2004. She obtained formal research training toward the acquisition
of an MPH from the University of Pittsburgh Graduate School of Public
Health. She has remained in Pittsburgh for an additional year of fellowship
after the T32, in part, to complete final coursework on her MPH, and
since she undertook some of her research training first. She continues
to work under the mentorship of Dr. Derek Angus (PT)—on
ICU outcomes. Drs. Kochanek and Clark were her ATs. Her work has focused
on evaluation of appropriateness of triage of pediatric TBI victims.
She presented an abstract on this project, using a database generated
from 7 states in the US, entitled “Is the management of severe
TBI in children in the US appropriately regionalized” at the 32nd
SCCM Congress. She found remarkable heterogeneous regionalization of
trauma care and a large number of children dying in non-tertiary centers.
A full manuscript of that work is in preparation. She is part of Dr.
Angus’ renowned CRISMA ICU outcomes group and is an author or co-author
of 8 abstracts and 2 editorials. We anticipate that her work will have
an important impact on the field. She plans to submit a K12 application
here at the University of Pittsburgh in early 2006, near the completion
of her clinical training.
Paul Shore, MD
Dr. Shore also completed his training
on the T-32 in June of 2004. His PT mentor was Dr. Kochanek and Drs.
Jackson, Adelson, Jenkins, and Wisniewski served as ATs. He studied both
the impact of the mode of CSF drainage and moderate hypothermia on ICP
and biochemical mediators in pediatric TBI—bridging bench to bedside.
He presented a paper at the SCCM Congress on continuous vs intermittent
CSF drainage after severe TBI in children and received an educational
scholarship. He also presented a paper at the 2003 WFPICCS Congress on
Critical Care on the impact of therapeutic hypothermia on the biochemical
response to TBI in children and won the Neuroscience award. He also completed
a “Masters of Clinical Research” and defended his thesis.
He published a manuscript in 2004 in Neurosurgery on vascular endothelial
growth factor in pediatric TBI and a second paper in the Journal of Neurotrauma
on the effect of continuous vs intermittent CSF drainage in pediatric
TBI. His third paper, in revision at Critical Care Medicine, defines
a tool (the PILOT scale) for quantifying treatment intensity for head
injured children. He also received a grant from the Laerdal Foundation.
Paul is now on the ICU faculty at the Dallas Children’s Hospital-University
of Texas Southwestern. He was specifically recruited to develop clinical
research in pediatric neurointensive care. He has already submitted a
K12 and plans to submit a K23. He has obtained IRB approval for a multi-center
RCT of CSF drainage method in pediatric TBI in Dallas. He is poised to
develop into a clinical investigator in pediatric neurointensive care.
Melinda
Fiedor, MD
Dr. Fiedor completed the T32 in 2005. She worked with
Dr. Schaefer as her PT, and Drs. Kochanek, Thompson, and Clark as ATs.
Her project involved the development and application of a new powerful
research and education tool—SimBaby® (Laerdal).
Dr. Fiedor worked on the development, beta testing, and initial evaluation
in clinical trials of this new tool for teaching resuscitation to pediatric
residents, medical students, fellows, EMS workers, and faculty. Her first
research study with this new tool was presented last Feb at the 2005
SCCM Congress. A full manuscript of that study is in preparation. This
is a unique opportunity involving WISER in the Department of Anesthesiology
at the University of Pittsburgh (directed by Dr Schaefer). She has also
written the first review article in the new field of human simulation
in pediatric resuscitation research, and published 3 abstracts and a
chapter on this novel topic. She also obtained a Masters degree in medical
education during her training on the T32 with a focus in medical education
research. We are only one of 3 sites in the world testing SimBaby® making
this a career-launching opportunity for her in simulation research in
pediatric resuscitation. Mindy joined our faculty this year and capitalized
on the value of SimBaby® and developed a simulation-based training
course for new PICU fellows that was implemented this July in our program.
It was extremely well-received.
Mandeep Chadha, MD
Dr. Chadha completed
work on the T32 this year. Dr. Larry Jenkins was his PT mentor in the
field of the application of proteomics to experimental research in
ischemia and TBI. Dr. Jenkins has the first publication of the use of
proteomics in TBI and is a superb mentor. Drs. Kochanek, Clark, and Wisniewski
served as ATs. Dr. Chadha presented his work on proteomics in brain injury
at 8 meetings. He has a full manuscript in preparation as first author
and will co-author numerous others in this emerging area. He presented
this work at the NICHD/NCMRR research trainee day (attended by ~200 trainees)
and it was selected as one of the top 3 papers. He just joined the
faculty at Dallas Children’s Hospital University of Texas Southwestern
and plans to continue his work in proteomics as a faculty member.
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