2016 Publications

Articles are listed in the order they are e-published.

December

Galantamine and Environmental Enrichment Enhance Cognitive Recovery after Experimental Traumatic Brain Injury But Do Not Confer Additional Benefits When Combined. de la Tremblaye PB, Bondi CO, Lajud N, Cheng JP, Radabaugh HL, Kline AE. J Neurotrauma. 2016 Dec 20. doi: 10.1089/neu.2016.4790.

Incidence and risk factors of posttraumatic seizures following traumatic brain injury: A Traumatic Brain Injury Model Systems Study. Ritter AC, Wagner AK, Fabio A, Pugh MJ, Walker WC, Szaflarski JP, Zafonte RD, Brown AW, Hammond FM, Bushnik T, Johnson-Greene D, Shea T, Krellman JW, Rosenthal JA, Dreer LE. Epilepsia. 2016 Dec;57(12):1968-1977. 

Autophagy Biomarkers Beclin 1 and p62 are Increased in Cerebrospinal Fluid after Traumatic Brain Injury. Au AK, Aneja RK, Bayır H, Bell MJ, Janesko-Feldman K, Kochanek PM, Clark RS.Neurocrit Care. 2016 Dec 20. [Epub ahead of print]

November

Traumatic brain injuries. Blennow K, Brody DL, Kochanek PM, Levin H, McKee A, Ribbers GM, Yaffe K, Zetterberg H. Nat Rev Dis Primers. 2016 Nov 17;2:16084.

October

Hidden Perils of the "Wild Blue Yonder" after Traumatic Brain Injury. Kochanek PM, Bayır H.J Neurotrauma. 2016 Oct 1;33(19):1729-1731.

A Dopamine Pathway Gene Risk Score for Cognitive Recovery Following Traumatic Brain Injury: Methodological Considerations, Preliminary Findings, and Interactions With Sex. Myrga JM, Failla MD, Ricker JH, Dixon CE, Conley YP, Arenth PM, Wagner AK. J Head Trauma Rehabil. 2016 Sep-Oct;31(5):E15-29.

September

The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol. Osier N, Dixon CE. Methods Mol Biol. 2016;1462:177-92. 

Enduring Disturbances in Regional Cerebral Blood Flow and Brain Oxygenation at 24 Hours after Asphyxial Cardiac Arrest in Developing Rats. Foley LM, Clark RS, Vazquez AL, Hitchens TK, Alexander H, Ho C, Kochanek PM, Manole MD. Pediatr Res. 2016 Sep 16. [Epub ahead of print]

ABCC8 Single Nucleotide Polymorphisms are Associated with Cerebral Edema in Severe TBI. Jha RM, Puccio AM, Okonkwo DO, Zusman BE, Park SY, Wallisch J, Empey PE, Shutter LA, Clark RS, Kochanek PM, Conley YP. Neurocrit Care. 2016 Sep 27. [Epub ahead of print]

Strategic Planning for Research in Pediatric Critical Care.Tamburro RF, Jenkins TL, Kochanek PM. Pediatr Crit Care Med. 2016 Sep 27. [Epub ahead of print]

Intermittent treatment with haloperidol or quetiapine does not disrupt motor and cognitive recovery after experimental brain trauma. Weeks JJ, Carlson LJ, Radabaugh HL, de la Tremblaye PB, Bondi CO, Kline AE. Behav Brain Res. 2016 Sep 21. [Epub ahead of print]

Abbreviated environmental enrichment confers neurobehavioral, cognitive, and histological benefits in brain-injured female rats. Radabaugh HL, Carlson LJ, O'Neil DA, LaPorte MJ, Monaco CM, Cheng JP, de la Tremblaye PB, Lajud Avila N, Bondi CO, Kline AE. 2016 Sep 28. [Epub ahead of print]

Imaging Mass Spectrometry Reveals Loss of Polyunsaturated Cardiolipins in the Cortical Contusion, Hippocampus and Thalamus after Traumatic Brain Injury. Sparvero LJ, Amoscato AA, Fink AB, Anthonymuthu T, New LE, Kochanek PM, Watkins S, Kagan VE, Bayır H. J Neurochem. 2016 Sep 3. [Epub ahead of print]

Effect of Hypothermia and Targeted Temperature Management on Drug Disposition and Response Following Cardiac Arrest: A Comprehensive Review of Preclinical and Clinical Investigations. Anderson KB, Poloyac SM, Kochanek PM, Empey PE.Ther Hypothermia Temp Manag. 2016 Sep 13. [Epub ahead of print]

Combined Neurotrauma Models: Experimental Models Combining Traumatic Brain Injury and Secondary Insults. Simon DW, Vagni VM, Kochanek PM, Clark RS. Methods Mol Biol. 2016;1462:393-411. 

August

The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol. Osier N, Dixon CE. Methods Mol Biol. 2016;1462:177-92. 

Mechanistic characterization of nitrite-mediated neuroprotection after experimental cardiac arrest. Dezfulian C, Kenny E, Lamade A, Misse A, Krehel N, St Croix C, Kelley EE, Jackson TC, Uray T, Rackley J, Kochanek PM, Clark RS, Bayir H. J Neurochem. 2016 Aug 10. [Epub ahead of print]

Pediatric Critical Care Medicine: Accomplishments and Important New Initiatives. Kochanek PM.Pediatr Crit Care Med. 2016 Aug;17(8):709.

June

Severe traumatic brain injury in children: a vision for the future. Bell MJ, Wisniewski SR. Intensive Care Med. 2016 Oct;42(10):1618-20. Epub 2016 Jun 2. 

Validation of the Pittsburgh Infant Brain Injury Score for Abusive Head Trauma. Berger RP, Fromkin J, Herman B, Pierce MC, Saladino RA, Flom L, Tyler-Kabara EC, McGinn T, Richichi R, Kochanek PM.Pediatrics. 2016 Jul;138(1). pii: e20153756. Epub 2016 Jun 23.

5-hydroxytryptamine1A (5-HT1A) receptor agonists: A decade of empirical evidence supports their use as an efficacious therapeutic strategy for brain trauma. Cheng JP, Leary JB, Sembhi A, Edwards CM, Bondi CO, Kline AE. Brain Res. 2016 Jun 1;1640(Pt A):5-14.

Combination therapies for neurobehavioral and cognitive recovery after experimental traumatic brain injury: Is more better? Kline AE, Leary JB, Radabaugh HL, Cheng JP, Bondi CO. Prog Neurobiol. 2016 Jul;142:45-67.

Serum Concentrations of Ubiquitin C-Terminal Hydrolase-L1 and Glial Fibrillary Acidic Protein after Pediatric Traumatic Brain Injury.Mondello S, Kobeissy F, Vestri A, Hayes RL, Kochanek PM, Berger RP.Sci Rep2016 Jun 20;6:28203. 

Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine.Hagos FT, Daood MJ, Ocque JA, Nolin TD, Bayir H, Poloyac SM, Kochanek PM, Clark RS, Empey PE.Xenobiotica2016 Jun 9:1-8. [Epub ahead of print]

Secondary Changes After Injury and Temperature. Batchelor P, Dietrich WD, Kochanek PM, Lundbye J.Ther Hypothermia Temp Manag2016 Jun;6(2):58-62. 

May

Variation in Anticonvulsant Selection and Electroencephalographic Monitoring Following Severe Traumatic Brain Injury in Children-Understanding Resource Availability in Sites Participating in a Comparative Effectiveness Study. Kurz JE, Poloyac SM, Abend NS, Fabio A, Bell MJ, Wainwright MS; for Investigators for the Approaches and Decisions in Acute Pediatric TBI Trial. Pediatr Crit Care Med. 2016 May 27. [Epub ahead of print]

The Therapeutic Efficacy of Environmental Enrichment and Methylphenidate Alone and in Combination after Controlled Cortical Impact Injury. Leary JB, Bondi CO, LaPorte MJ, Carlson LJ, Radabaugh HL, Cheng JP,Kline AE.

Relative to Typical Antipsychotic Drugs, Aripiprazole Is a Safer Alternative for Alleviating Behavioral Disturbances After Experimental Brain Trauma. Phelps TI, Bondi CO, Mattiola VV, Kline AE.Neurorehabil Neural Repair2016 May 24. [Epub ahead of print]

Variation in PPP3CC genotype is associated with long-term recovery after severe brain injury.Osier N, Bales JW, Pugh BJ, Shin S, Wyrobek J, Puccio AM, Okonkwo DO, Ren D, Alexander SA, Conley YP, Dixon CEJ Neurotrauma2016 May 25. [Epub ahead of print]

April

Combining the Antipsychotic Drug Haloperidol and Environmental Enrichment after Traumatic Brain Injury Is a Double-Edged Sword. Folweiler KA, Bondi CO, Ogunsanya EA, LaPorte MJ, Leary JB, Radabaugh HL, Monaco CM, Kline AE. J Neurotrauma. 2016 Apr 20. [Epub ahead of print] 

Rosiglitazone attenuates inflammation and CA3 neuronal loss following traumatic brain injury in rats.Liu H, Rose ME, Culver S, Ma X, Dixon CE, Graham SH.

Insight into Pre-Clinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy. Mondello S, Shear DA, Bramlett HM, Dixon CE, Schmid KE, Dietrich WD, Wang KK, Hayes RL, Glushakova O, Catania M, Richieri SP, Povlishock JT, Tortella FC, Kochanek PM. J Neurotrauma. 2016 Mar 15;33(6):595-605.

Effectiveness of Pharmacological Therapies for Intracranial Hypertension in Children With Severe Traumatic Brain Injury-Results From an Automated Data Collection System Time-Synched to Drug Administration.Shein SL, Ferguson NM, Kochanek PM, Bayir H, Clark RS, Fink EL, Tyler-Kabara EC, Wisniewski SR, Tian Y, Balasubramani GK, Bell MJ.Pediatr Crit Care Med2016 Mar;17(3):236-45.

Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.Browning M, Shear DA, Bramlett HM, Dixon CE, Mondello S, Schmid KE, Poloyac SM, Dietrich WD, Hayes RL, Wang KKW, Povlishock JT, Tortella FC, Kochanek PM. J Neurotrauma 33:581-594, 2016. 

Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy.Kochanek PM, Bramlett HM, Shear DA, Dixon CE, Mondello S, Dietrich WD, Hayes RL, Wang KK, Poloyac SM, Empey PE, Povlishock JT, Mountney A, Browning M, Deng-Bryant Y, Yan HQ, Jackson TC, Catania M, Glushakova O, Richieri SP, Tortella FC.J Neurotrauma2016 Mar 15;33(6):606-14. 

Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy. Dixon CE, Bramlett HM, Dietrich WD, Shear DA, Yan HQ, Deng-Bryant Y, Mondello S, Wang KK, Hayes RL, Empey PE, Povlishock JT, Tortella FC, Kochanek PMJ Neurotrauma2016 Mar 15;33(6):553-66. 

Nicotinamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.Shear DA, Dixon CE, Bramlett HM, Mondello S, Dietrich WD, Deng-Bryant Y, Schmid KE, Wang KK, Hayes RL, Povlishock JT, Kochanek PM, Tortella FC. J Neurotrauma2016 Mar 15;33(6):523-37. 

Erythropoietin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy. Bramlett HM, Dietrich WD, Dixon CE, Shear DA, Schmid KE, Mondello S, Wang KK, Hayes RL, Povlishock JT, Tortella FC, Kochanek PM.J Neurotrauma2016 Mar 15;33(6):538-52.

Probenecid and N-Acetylcysteine Prevent Loss of Intracellular Glutathione and Inhibit Neuronal Death after Mechanical Stretch Injury In Vitro. Du L, Empey PE, Ji J, Chao H, Kochanek PM, Bayır H, Clark RS.J Neurotrauma. 2016 Mar 22. [Epub ahead of print]

Intracranial Hypertension and Cerebral Hypoperfusion in Children with Severe Traumatic Brain Injury: Thresholds and Burden in Accidental and Abusive Insults. Miller Fergusion N, Shein SL, Kochanek PM, Luther J, Wisniewski SR, Clark RS, Tyler-Kabara EC, Adelson PD, Bell MJ. Pediatr Crit Care Med. 2016 Mar 29 [Epub ahead of print].

Oxygen: A Luxurious Life-Giving and Potentially Toxic Gas. Sanchez-de-Toledo J, Bayir H. Pediatr Crit Care Med. 2016 Apr;17(4):371-2.

February

Therapies targeting lipid peroxidation in traumatic brain injury.Anthonymuthu TS, Kenny EM, Bayır H.Brain Res2016 Jun 1;1640(Pt A):57-76.

Brain Injury and Revcovery. Kline AE, Bondi CO. Brain Res. 2016 Feb 25 [Epub ahead of print].

Ultrastructure of diaschisis lesions following traumatic brain injury.Wiley CA, Bissel SJ, Lesniak A, Dixon CE, Franks J, Stolz DB, Sun M, Wang G, Switzer Iii RC, Kochanek PM, Murdoch GH.J Neurotrauma. 2016 Feb 25. [Epub ahead of print]

Probenecid and N-acetylcysteine Prevent Loss of Intracellular Glutathione and Inhibit Neuronal Death after Mechanical Stretch Injury In Vitro. Du L, Empey P, Ji J, Chao H, Kochanek PM, Bayir H, Clark R. J Neurotrauma. 2016 Feb 2. [Epub ahead of print].

Purines: Forgotten Mediators in Traumatic Brain Injury. Jackson EK, Boison D, Schwarzschild MA, Kochanek PM. J Neurochem. 2016 Jan 26. doi: 10.1111/jnc.13551. [Epub ahead of print].

Exploratory Study of Serum Ubiquitin Carboxyl-Terminal Esterase L1 and Glial Fibrillary Acidic Protein for Outcome Prognostication after Pediatric Cardiac Arrest. Fink EL, Berger RP, Clark RS, Watson RS, Angus DC, Panigrahy A, Richichi R, Callaway CW, Bell MJ, Mondello S, Hayes RL, Kochanek PM. Resuscitation. 2016 Feb 5. [Epub ahead of print].

January

Pediatric Critical Care Medicine 2016: Growth and Further Specialization. Kochanek PM.Pediatr Crit Care Med. 2016 Jan;17(1):1. 

Purines: Forgotten Mediators in Traumatic Brain Injury. Jackson EK, Boison D, Schwarzschild MA, Kochanek PM. J Neurochem. 2016 Jan 26. [Epub ahead of print].

Genetic Variation in the Vesicular Monoamine Transporter: Preliminary Associations With Cognitive Outcomes After Severe Traumatic Brain Injury. Markos SM, Failla MD, Ritter AC, Dixon CE, Conley YP, Ricker JH, Arenth PM, Juengst SB, Wagner AK. J Head Trauma Rehabil. 2016 Jan 29. [Epub ahead of print].

Operation Brain Trauma Therapy: Simvastatin Treatment in Traumatic Brain Injury. Mountney A, Bramlett HM, Dixon CE, Mondello S. Dietrich WD, Caudle K, Empey PE, Poloyac SM, Hayes RL, Povlishock JT, Tortella FC, Kochanek PM, Shear DA. J Neurotrauma 2016 Jan 20 [Epub ahead of print].

Effects of Depression and Antidepressant Use on Cognitive Deficits and Functional Cognition Following Severe Traumatic Brain Injury. Failla MD, Juengst SB, Graham KM, Arenth PM, Wagner AK. J Head Trauma Rehabil. 2016 Jan 29. [Epub ahead of print].

Brain-Derived Neurotrophic Factor (BDNF) in Traumatic Brain Injury-Related Mortality: Interrelationships Between Genetics and Acute Systemic and Central Nervous System BDNF Profiles. Failla MD, Conley YP, Wagner AK. Neurorehabil Neural Repair. 2016 Jan;30(1):83-93.